Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SOAT1 | P35610 | 5/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | EPHX1 | P07099 | 5/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9000575 | 0.94 | SOAT1 (0.39) | SOAT1ALDH1A1SMN1; SMN2CYP1A2CYP3A4 | |
| SCHEMBL9000506 | 0.94 | SOAT1 (0.39) | SOAT1ALDH1A1SMN1; SMN2POLBNPSR1 | |
| SCHEMBL9000753 | 0.93 | SOAT1 (0.39) | SOAT1ALDH1A1SMN1; SMN2EPHX1POLB | |
| SCHEMBL9000445 | 0.93 | POLB (0.43) | SOAT1ALDH1A1EPHX1POLB | |
| SCHEMBL9000604 | 0.92 | EPHX1 (0.47) | SOAT1ALDH1A1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL9000588 | 0.92 | EPHX1 (0.38) | SOAT1ALDH1A1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL9000398 | 0.92 | EPHX1 (0.47) | SOAT1SMN1; SMN2EPHX1 | |
| SCHEMBL9000677 | 0.91 | EPHX1 (0.42) | SOAT1EPHX1NPSR1 | |
| SCHEMBL9000673 | 0.90 | SOAT1 (0.37) | SOAT1EPHX1 | |
| SCHEMBL9000839 | 0.90 | SOAT1 (0.38) | SOAT1ALDH1A1SMN1; SMN2CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5583147-A | INHIBITORS OF ACYL-COENZYME A: CHOLESTEROL O-TRANSFERASE; ANTIHYPERCHOLESTEROLEMIC AND/OR ANTIATHEROSCLEROTIC AGENTS | THE DUPONT MERCK PHARMACEUTICAL COMPANY (US) | 1996-12-10 | — | — | US | disclosed |