Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | SOAT1 | P35610 | 6/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9000887 | 0.95 | LMNA (0.39) | MAPTLMNAMEN1KMT2AGAA | |
| SCHEMBL9000950 | 0.95 | MAPT (0.46) | MAPTLMNAMEN1KMT2AGAA | |
| SCHEMBL9000530 | 0.93 | MAPT (0.41) | MAPTLMNAMEN1KMT2AGAA | |
| SCHEMBL9000883 | 0.93 | MAPT (0.41) | MAPTLMNAMEN1KMT2AGAA | |
| SCHEMBL9000744 | 0.93 | MAPT (0.38) | MAPTLMNAMEN1KMT2AGAA | |
| SCHEMBL9000592 | 0.88 | MAPT (0.44) | MAPTLMNAMEN1KMT2AGAA | |
| SCHEMBL9000815 | 0.87 | MAPT (0.50) | MAPTLMNAMEN1KMT2AGAA | |
| SCHEMBL9000745 | 0.85 | EPHX1 (0.41) | MAPTLMNAMEN1KMT2AGAA | |
| SCHEMBL9000496 | 0.85 | MAPT (0.44) | MAPTLMNAMEN1KMT2ATDP1 | |
| SCHEMBL9000642 | 0.83 | MAPT (0.41) | MAPTLMNAMEN1KMT2AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5583147-A | INHIBITORS OF ACYL-COENZYME A: CHOLESTEROL O-TRANSFERASE; ANTIHYPERCHOLESTEROLEMIC AND/OR ANTIATHEROSCLEROTIC AGENTS | THE DUPONT MERCK PHARMACEUTICAL COMPANY (US) | 1996-12-10 | — | — | US | disclosed |