Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | PRNP | P04156 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9000530 | 0.95 | MAPT (0.41) | MAPTLMNAALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL9000883 | 0.95 | MAPT (0.41) | MAPTLMNAALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL9000642 | 0.95 | MAPT (0.41) | MAPTLMNAALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL9000852 | 0.95 | MAPT (0.52) | MAPTLMNAALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL9000802 | 0.93 | MAPT (0.39) | MAPTLMNAALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL9000902 | 0.88 | MAPT (0.42) | MAPTLMNAMEN1KMT2ATDP1 | |
| SCHEMBL9000423 | 0.85 | EPHX1 (0.44) | MAPTLMNAALDH1A1SMN1; SMN2NPSR1 | |
| SCHEMBL9000815 | 0.85 | MAPT (0.50) | MAPTLMNAALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL9000887 | 0.83 | LMNA (0.39) | MAPTLMNASMN1; SMN2NPSR1MEN1 | |
| SCHEMBL9000496 | 0.83 | MAPT (0.44) | MAPTLMNAALDH1A1HTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5583147-A | INHIBITORS OF ACYL-COENZYME A: CHOLESTEROL O-TRANSFERASE; ANTIHYPERCHOLESTEROLEMIC AND/OR ANTIATHEROSCLEROTIC AGENTS | THE DUPONT MERCK PHARMACEUTICAL COMPANY (US) | 1996-12-10 | — | — | US | disclosed |