Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.43 |
| ▸ | PKM | P14618 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | APP | P05067 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9002031 | 0.85 | ACHE (0.34) | ALDH1A1HSD17B10HPGDTDP1SMN1; SMN2 | |
| SCHEMBL9002520 | 0.84 | ACHE (0.43) | HPGDSMN1; SMN2HTT | |
| SCHEMBL9001895 | 0.84 | ACHE (0.38) | ALDH1A1HSD17B10HPGDTDP1 | |
| SCHEMBL9002724 | 0.83 | KDM4E (0.45) | ALDH1A1SMN1; SMN2GAAMAPK1KDM4E | |
| SCHEMBL9002366 | 0.79 | ACHE (0.39) | ALDH1A1HPGDL3MBTL1GAALMNA | |
| SCHEMBL9001857 | 0.78 | HPGD (0.34) | HPGDSMN1; SMN2L3MBTL1NPC1MAPK1 | |
| SCHEMBL9002395 | 0.78 | LMNA (0.34) | ALDH1A1HSD17B10SMN1; SMN2L3MBTL1GAA | |
| SCHEMBL9002205 | 0.77 | ALDH1A1 (0.39) | ALDH1A1HPGDTDP1SMN1; SMN2PKM | |
| SCHEMBL9002818 | 0.77 | ALDH1A1 (0.38) | ALDH1A1HSD17B10HPGDTDP1SMN1; SMN2 | |
| SCHEMBL9001998 | 0.76 | SMN1; SMN2 (0.34) | SMN1; SMN2MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5587383-A | CALMODULIN INHIBITORS; ANTIISCHEMIC AGENTS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1996-12-24 | — | — | US | disclosed |
| EP-0471236-B1 | Imidazopyridine derivatives and their use | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1995-03-15 | — | — | EP | disclosed |
| US-5395839-A | Calmodulin and angiogenesis inhibitors | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1995-03-07 | — | — | US | disclosed |
| US-5244908-A | Calmodulin inhibitors | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1993-09-14 | — | — | US | disclosed |
| EP-0471236-A1 | Imidazopyridine derivatives and their use | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1992-02-19 | — | — | EP | disclosed |