Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | RELA | Q04206 | 4/20 | 0.34 |
| ▸ | BRAF | P15056 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | CNR2 | P34972 | 1/20 | 0.32 |
| ▸ | HRH1 | P35367 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9001931 | 1.00 | KDM4E (0.39) | KDM4EHPGDRELABRAFPOLB | |
| SCHEMBL9002291 | 0.96 | HPGD (0.35) | KDM4EHPGDCNR2HRH1KCNH2 | |
| SCHEMBL9002373 | 0.91 | KDM4E (0.36) | KDM4EALDH1A1GAAMAPT | |
| SCHEMBL9002202 | 0.88 | CHEK1 (0.32) | ALDH1A1 | |
| SCHEMBL9002172 | 0.82 | MAPT (0.43) | POLBALDH1A1GAAMAPT | |
| SCHEMBL9002262 | 0.79 | NPY5R (0.33) | ALDH1A1GAAMAPT | |
| SCHEMBL9002013 | 0.78 | POLB (0.37) | POLBALDH1A1MAPT | |
| SCHEMBL9001975 | 0.77 | KMT2A (0.47) | KDM4EPOLBALDH1A1GAAMAPT | |
| SCHEMBL9002010 | 0.77 | POLB (0.36) | POLBCNR2ALDH1A1MAPT | |
| SCHEMBL9002239 | 0.76 | ALDH1A1 (0.49) | POLBALDH1A1GAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5587383-A | CALMODULIN INHIBITORS; ANTIISCHEMIC AGENTS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1996-12-24 | — | — | US | disclosed |
| EP-0471236-B1 | Imidazopyridine derivatives and their use | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1995-03-15 | — | — | EP | disclosed |
| US-5395839-A | Calmodulin and angiogenesis inhibitors | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1995-03-07 | — | — | US | disclosed |
| US-5244908-A | Calmodulin inhibitors | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1993-09-14 | — | — | US | disclosed |
| EP-0471236-A1 | Imidazopyridine derivatives and their use | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1992-02-19 | — | — | EP | disclosed |