Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.64 |
| ▸ | MEN1 | O00255 | 1/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.64 |
| ▸ | VNN1 | O95497 | 10/20 | 0.64 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.60 |
| ▸ | CES2 | O00748 | 1/20 | 0.57 |
| ▸ | TBXAS1 | P24557 | 2/20 | 0.56 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.56 |
| ▸ | CASP1 | P29466 | 1/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.56 |
| ▸ | CSF1R | P07333 | 1/20 | 0.55 |
| ▸ | BRAF | P15056 | 1/20 | 0.55 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.55 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.53 |
| ▸ | CNR2 | P34972 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10663373 | 0.89 | TSHR (0.55) | TSHRMEN1KMT2AVNN1SRD5A2 | |
| SCHEMBL10841345 | 0.88 | CES2 (0.72) | TSHRMEN1KMT2AVNN1SRD5A2 | |
| SCHEMBL1237189 | 0.85 | SRD5A2 (0.79) | MEN1KMT2AVNN1SRD5A2CES2 | |
| SCHEMBL30706506 | 0.84 | VNN1 (0.60) | TSHRMEN1KMT2AVNN1SRD5A2 | |
| SCHEMBL15648102 | 0.84 | VNN1 (0.60) | TSHRMEN1KMT2AVNN1SRD5A2 | |
| SCHEMBL1044812 | 0.80 | SRD5A2 (0.83) | VNN1SRD5A2CES2NPSR1CNR2 | |
| SCHEMBL18286220 | 0.79 | VNN1 (1.00) | VNN1 | |
| SCHEMBL1242243 | 0.79 | ALDH1A1 (0.71) | MEN1KMT2A | |
| SCHEMBL29915528 | 0.79 | ALDH1A1 (0.71) | MEN1KMT2A | |
| SCHEMBL30706504 | 0.79 | AGTR1 (0.57) | MEN1KMT2ACES2TBXAS1CSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5482948-A | Pyridyl derivatives and pharmaceutical compositions comprising these compounds | DR. KARL THOMAE GMBH (DE) | 1996-01-09 | — | — | US | disclosed |
| EP-0547517-B1 | Pyridyl derivatives, medicines containing these compounds and processes for their preparation | THOMAE GMBH DR K (DE) | 1995-05-17 | — | — | EP | disclosed |
| EP-0547517-A1 | Pyridyl derivatives, medicines containing these compounds and processes for their preparation | Dr. Karl Thomae GmbH (DE) | 1993-06-23 | — | — | EP | disclosed |