SCHEMBL900273

SCHEMBL900273

FC(F)Oc1c[c]cc(Cl)c1

nearest known ligand 0.34

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
LMNA P02545 2/20 0.34
MEN1 O00255 1/20 0.34
MAPT P10636 1/20 0.34
RAB9A P51151 1/20 0.34
KMT2A Q03164 1/20 0.34
NPSR1 Q6W5P4 1/20 0.34
SENP8 Q96LD8 1/20 0.34
SENP7 Q9BQF6 1/20 0.34
SENP6 Q9GZR1 1/20 0.34
GAA P10253 2/20 0.31
SMN1; SMN2 Q16637 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL900768 0.86 DRD1 (0.33) LMNAMEN1MAPTKMT2A
SCHEMBL28987498 0.80
SCHEMBL16951401 0.78 ALDH1A1 (0.33) LMNAKMT2AGAA
SCHEMBL900739 0.78
SCHEMBL1067020 0.77 MAPT (0.41) LMNAMEN1MAPTRAB9AKMT2A
SCHEMBL1066949 0.77
SCHEMBL16956555 0.77 ALOX15 (0.32)
SCHEMBL1064063 0.77 MEN1 (0.31) LMNAMEN1KMT2ASMN1; SMN2
SCHEMBL5850517 0.77 APP (0.33)
SCHEMBL1068589 0.77 ALOX15 (0.32)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 72 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-112204021-B Novel heteroaryl triazoles and heteroaryl tetrazoles as pesticides 拜耳公司 2024-05-28 CN claimed
EP-3784661-B1 NOVEL HETEROARYL-TRIAZOLE AND HETEROARYL-TETRAZOLE COMPOUNDS AS PESTICIDES BAYER AG (DE) 2023-11-22 EP claimed
EP-3919486-B1 NOVEL HETEROARYL-TRIAZOLE AND HETEROARYL-TETRAZOLE COMPOUNDS AS PESTICIDES BAYER AG (DE) 2023-06-07 EP claimed
CN-114423748-A Novel heteroaryl triazole compounds as pesticides 拜耳公司 2022-04-29 CN claimed
CN-112204021-A Novel heteroaryltriazole and heteroaryltetrazole compounds as pesticides 拜耳公司 2021-01-08 CN claimed
CN-101407453-A A process for resolving, optionally substituted, mandelic acids by salt formation with a chiral base cyclic amide ASTRAZENECA AB (SE) 2009-04-15 CN claimed
CN-1886359-A Process for resolving optionally substituted mandelic acids by salt formation with chiral base cyclic amides ASTRAZENECA AB (SE) 2006-12-27 CN claimed
CN-112204021-B Novel heteroaryl triazoles and heteroaryl tetrazoles as pesticides 拜耳公司 2024-05-28 CN disclosed
CN-114423748-A Novel heteroaryl triazole compounds as pesticides 拜耳公司 2022-04-29 CN disclosed
CN-114127062-A Thiadiazolyl derivatives as inhibitors of DNA polymerase Theta 伊迪亚生物科学有限公司 2022-03-01 CN disclosed
CN-107690434-B Fused tricyclic imidazopyrazine derivatives as modulators of TNF activity UCB生物制药私人有限公司 2021-07-30 CN disclosed
CN-112204021-A Novel heteroaryltriazole and heteroaryltetrazole compounds as pesticides 拜耳公司 2021-01-08 CN disclosed
EP-3303337-B1 FUSED TRICYCLIC IMIDAZO PYRAZINES AS MODULATORS OF TNF ACTIVITY UCB Biopharma SRL (BE) 2020-05-27 EP disclosed
US-20100311581-A1 Azolylmethyloxiranes, use Thereof and Agents Containing the Same BASF SE (DE) 2010-12-09 US disclosed
CN-101902914-A Azolylmethyloxiranes, use thereof and compositions comprising same BASF SE 2010-12-01 CN disclosed
US-20100273651-A1 Azolylmethyloxiranes, use Thereof and Agents Containing the Same BASF SE (DE) 2010-10-28 US disclosed
CN-101407453-A A process for resolving, optionally substituted, mandelic acids by salt formation with a chiral base cyclic amide ASTRAZENECA AB (SE) 2009-04-15 CN disclosed
CN-100448834-C Process for resolving optionally substituted mandelic acids by salt formation with chiral base cyclic amides ASTRAZENECA AB (SE) 2009-01-07 CN disclosed
CN-101180256-A Method for kinetic resolution of (substituted) (R) -or (S) -mandelic acids ASTRAZENECA AB ASTRAZENECA UK (SE) 2008-05-14 CN disclosed
CN-1886359-A Process for resolving optionally substituted mandelic acids by salt formation with chiral base cyclic amides ASTRAZENECA AB (SE) 2006-12-27 CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100273651-A1 Azolylmethyloxiranes, use Thereof and Agents Containing the Same XDH, SQOR, NOX5 LMNA 4264/4885MEN1 1585/4885MAPT 3863/4885
US-20100311581-A1 Azolylmethyloxiranes, use Thereof and Agents Containing the Same XDH, DAO, DHODH LMNA 4292/4885MEN1 1626/4885MAPT 3819/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.