Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | AKR1C3 | P42330 | 10/20 | 0.43 |
| ▸ | AKR1C2 | P52895 | 10/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | TPMT | P51580 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27801015 | 0.89 | TPMT (0.49) | HSD17B10KDM4EALDH1A1HPGDTPMT | |
| SCHEMBL2796551 | 0.85 | LMNA (0.52) | LMNAALDH1A1TPMTMAPT | |
| SCHEMBL11111361 | 0.82 | LMNA (0.56) | HSD17B10LMNAAKR1C3AKR1C2KDM4E | |
| SCHEMBL1434189 | 0.81 | HSD17B10 (0.52) | HSD17B10KDM4EALDH1A1HPGDTPMT | |
| SCHEMBL11618007 | 0.80 | ATM (0.47) | HSD17B10LMNAAKR1C3KDM4EALDH1A1 | |
| SCHEMBL10920134 | 0.79 | KDM4E (0.55) | HSD17B10AKR1C3AKR1C2KDM4EALDH1A1 | |
| SCHEMBL11617870 | 0.79 | THRA (0.44) | HSD17B10KDM4EALDH1A1HPGDTDP1 | |
| SCHEMBL19100974 | 0.78 | HSD17B10 (0.49) | HSD17B10KDM4EALDH1A1HPGDMAPT | |
| SCHEMBL786462 | 0.78 | LMNA (0.60) | LMNAKDM4EALDH1A1HPGDTPMT | |
| SCHEMBL2978683 | 0.78 | LMNA (0.50) | HSD17B10LMNAKDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0733037-A1 | ARYL SUBSTITUTED AMINO ACIDS, CNS INFLUENCING AGENTS | UNIVERSITY OF BRISTOL (GB) | 1996-09-25 | — | — | EP | disclosed |
| WO-1995015941-A1 | ARYL SUBSTITUTED AMINO ACIDS, CNS INFLUENCING AGENTS | UNIVERSITY OF BRISTOL (GB) | 1995-06-15 | — | — | WO | disclosed |
| US-4301159-A | FOR GASTRIC DISORDERS, ANTIEMETICS | SHIONOGI & CO., LTD. (JP) | 1981-11-17 | — | — | US | disclosed |
| US-4127666-A | ANTIEMETIC | UNIVERSITE D'ORLEANS (FR) | 1978-11-28 | — | — | US | disclosed |