Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 2/20 | 0.46 |
| ▸ | MMP2 | P08253 | 2/20 | 0.46 |
| ▸ | MMP3 | P08254 | 2/20 | 0.46 |
| ▸ | MMP8 | P22894 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | FDPS | P14324 | 3/20 | 0.32 |
| ▸ | MLYCD | O95822 | 1/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10850693 | 0.80 | MMP1 (0.53) | MMP1MMP2MMP3MMP8FDPS | |
| SCHEMBL578487 | 0.80 | FDPS (0.33) | MMP1MMP2MMP3MMP8FDPS | |
| SCHEMBL18486528 | 0.77 | GGPS1 (0.52) | FDPS | |
| SCHEMBL9070271 | 0.77 | GGPS1 (0.52) | FDPS | |
| SCHEMBL6614297 | 0.74 | — | — | |
| SCHEMBL18486699 | 0.72 | MMP1 (0.41) | MMP1MMP2MMP3MMP8LMNA | |
| SCHEMBL6051813 | 0.72 | FDPS (0.37) | MMP1MMP2MMP3MMP8LMNA | |
| SCHEMBL3281290 | 0.72 | FDPS (0.37) | MMP1MMP2MMP3MMP8LMNA | |
| SCHEMBL282438 | 0.72 | FDPS (0.37) | LMNAFDPS | |
| SCHEMBL10424196 | 0.71 | CYP3A4 (0.38) | MMP1MMP2MMP3MMP8LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5543406-A | TREATING ANDROGEN RESPONSIVE OR MEDIATED DISEASE | GLAXO WELLCOME, INC. (US) | 1996-08-06 | — | — | US | disclosed |
| EP-0641356-A1 | INHIBITORS OF 5-ALPHA-TESTOSTERONE REDUCTASE | GLAXO WELLCOME INC. (US) | 1995-03-08 | — | — | EP | disclosed |
| WO-1993013124-A1 | INHIBITORS OF 5-ALPHA-TESTOSTERONE REDUCTASE | GLAXO INC. (US) | 1993-07-08 | — | — | WO | disclosed |
| US-4564477-A | DOLICHOL INTERMEDIATE | KURARAY CO., LTD. (JP) | 1986-01-14 | — | — | US | disclosed |
| EP-0087136-B1 | NOVEL POLYPRENYL COMPOUNDS, METHOD OF PRODUCING THE SAME AND THEIR USE IN DOLICHOL PRODUCTION | KURARAY CO., LTD. (JP) | 1985-07-31 | — | — | EP | disclosed |
| EP-0087136-A2 | Novel polyprenyl compounds, method of producing the same and their use in dolichol production | KURARAY CO., LTD. (JP) | 1983-08-31 | — | — | EP | disclosed |
| US-4388237-A | NEUROLEPTIC, SEDATIVE, HYPNOTIC, ANALGESIC, ANTIDEPRESSANT | BASF AKTIENGESELLSCHAFT (DE) | 1983-06-14 | — | — | US | disclosed |
| EP-0019172-A1 | 6-Substituted 11-alkylene-morphantridines, process for preparing them and pharmaceutical compositions containing them | BASF Aktiengesellschaft (DE) | 1980-11-26 | — | — | EP | disclosed |
| US-4172146-A | Substituted phenyl derivatives | CIBA-GEIGY CORPORATION (US) | 1979-10-23 | — | — | US | disclosed |
| US-4069344-A | INSECTICIDAL SUBSTITUTED PHENYL DERIVATIVES | CIBA-GEIGY CORPORATION (US) | 1978-01-17 | — | — | US | disclosed |
| US-3983243-A | INSECTICIDES | HOFFMANN-LA ROCHE INC. (US) | 1976-09-28 | — | — | US | disclosed |