Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGLL | Q99685 | 1/20 | 0.43 |
| ▸ | PTPN11 | Q06124 | 2/20 | 0.41 |
| ▸ | DRD4 | P21917 | 2/20 | 0.40 |
| ▸ | CTSS | P25774 | 3/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.36 |
| ▸ | PIM1 | P11309 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | JAK1 | P23458 | 1/20 | 0.35 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.35 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.35 |
| ▸ | LCAT | P04180 | 1/20 | 0.34 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.34 |
| ▸ | ACACB | O00763 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7391156 | 0.92 | CTSS (0.40) | MGLLPTPN11DRD4CTSSHTR1A | |
| Hydrochloric Acid SCHEMBL9005437 | 0.91 | CTSS (0.39) | MGLLPTPN11DRD4CTSSHTR1A | |
| Oxalic Acid SCHEMBL9005357 | 0.78 | PRKCQ (0.48) | MGLLCTSSPIM1JAK2JAK1 | |
| SCHEMBL7391630 | 0.77 | PTPN11 (0.50) | PTPN11PIM1 | |
| Oxalic Acid SCHEMBL9005348 | 0.74 | CTSS (0.51) | CTSSPIM1LCATIRAK4 | |
| SCHEMBL7391751 | 0.70 | HSD11B1 (0.42) | PTPN11PIM1HCRTR1HCRTR2ACACB | |
| Hydrochloric Acid SCHEMBL9005386 | 0.69 | HSD11B1 (0.41) | PTPN11PIM1HCRTR1HCRTR2ACACB | |
| SCHEMBL7391155 | 0.68 | PRKCQ (0.45) | CTSSPIM1IRAK4 | |
| SCHEMBL7392572 | 0.67 | HTR3E (0.50) | PTPN11PIM1ACACB | |
| Hydrochloric Acid SCHEMBL9005436 | 0.67 | PRKCQ (0.44) | CTSSPIM1IRAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5576320-A | 1-heteruarylazetidines and -pyrrolidines, process for their preparation and pharmaceutical compositions containing them | SANOFI (FR) | 1996-11-19 | — | — | US | disclosed |
| US-5565474-A | 1-heteroarylazetidines and -pyrrolidines process for their preparation and pharmaceutical compositions containing them | SANOFI (FR) | 1996-10-15 | — | — | US | disclosed |
| US-5410057-A | 1-heteroarylazetidines and -pyrrolidines | SANOFI (FR) | 1995-04-25 | — | — | US | disclosed |