Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 4/20 | 0.51 |
| ▸ | PIM1 | P11309 | 4/20 | 0.49 |
| ▸ | PRKCQ | Q04759 | 3/20 | 0.49 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | HTR3B | O95264 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | HTR3A | P46098 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.44 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.44 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.43 |
| ▸ | HRH4 | Q9H3N8 | 3/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | LCAT | P04180 | 1/20 | 0.41 |
| ▸ | PIM3 | Q86V86 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7391451 | 0.92 | CTSS (0.54) | CTSSPIM1PRKCQHTR3EMEN1 | |
| Oxalic Acid SCHEMBL9005357 | 0.79 | PRKCQ (0.48) | CTSSPIM1PRKCQIRAK4LCAT | |
| SCHEMBL9005452 | 0.78 | PRKCQ (0.63) | PIM1PRKCQHTR3EMEN1HTR3B | |
| SCHEMBL18754556 | 0.75 | CTSS (0.51) | CTSSPIM1HTR3EMEN1HTR3B | |
| Oxalic Acid SCHEMBL9005359 | 0.74 | MGLL (0.43) | CTSSPIM1IRAK4LCAT | |
| SCHEMBL20140586 | 0.73 | PARP1 (0.44) | CTSSMEN1TSHRKMT2ALCAT | |
| SCHEMBL21730336 | 0.73 | CTSS (0.51) | CTSSHTR3AHRH4HRH3 | |
| SCHEMBL29907733 | 0.73 | CTSS (0.51) | CTSSHTR3AHRH4HRH3 | |
| SCHEMBL15014503 | 0.73 | CTSS (0.50) | CTSSHTR3EMEN1HTR3BCYP1A2 | |
| SCHEMBL2952412 | 0.72 | CTSS (0.48) | CTSSPIM1HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5576320-A | 1-heteruarylazetidines and -pyrrolidines, process for their preparation and pharmaceutical compositions containing them | SANOFI (FR) | 1996-11-19 | — | — | US | disclosed |
| US-5565474-A | 1-heteroarylazetidines and -pyrrolidines process for their preparation and pharmaceutical compositions containing them | SANOFI (FR) | 1996-10-15 | — | — | US | disclosed |
| US-5410057-A | 1-heteroarylazetidines and -pyrrolidines | SANOFI (FR) | 1995-04-25 | — | — | US | disclosed |