SCHEMBL9006445

SCHEMBL9006445

CC(=O)c1ccc(C=Cc2ccc(OC(F)=C(F)F)cc2)cc1

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 5/20 0.55
MAPT P10636 3/20 0.49
SMN1; SMN2 Q16637 3/20 0.49
LMNA P02545 2/20 0.49
KDM4E B2RXH2 1/20 0.49
MEN1 O00255 1/20 0.49
TTR P02766 1/20 0.49
TP53 P04637 1/20 0.49
CYP3A4 P08684 1/20 0.49
RAB9A P51151 2/20 0.47
HPGD P15428 1/20 0.47
TUBB4A P04350 2/20 0.42
TUBB P07437 2/20 0.42
TUBA3C P0DPH7 2/20 0.42
TUBA1B P68363 2/20 0.42
TUBA4A P68366 2/20 0.42
TUBB4B P68371 2/20 0.42
TUBB3 Q13509 2/20 0.42
TUBB2A Q13885 2/20 0.42
TUBB8 Q3ZCM7 2/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9006442 1.00 KMT2A (0.55) KMT2AMAPTSMN1; SMN2LMNAKDM4E
SCHEMBL9006530 0.91 KMT2A (0.57) KMT2AMAPTSMN1; SMN2LMNAKDM4E
SCHEMBL9006488 0.90 MAPT (0.57) KMT2AMAPTSMN1; SMN2LMNARAB9A
SCHEMBL9006431 0.86 ESR1 (0.45) KMT2AMAPTSMN1; SMN2LMNARAB9A
SCHEMBL9006426 0.86 ESR1 (0.45) KMT2AMAPTSMN1; SMN2LMNARAB9A
SCHEMBL9006474 0.84 KDM4E (0.44) KMT2AMAPTSMN1; SMN2LMNAKDM4E
SCHEMBL9006467 0.84 KDM4E (0.44) KMT2AMAPTSMN1; SMN2LMNAKDM4E
SCHEMBL9006644 0.83 KMT2A (0.49) KMT2ALMNAMEN1F3BCHE
SCHEMBL9006814 0.82 GLA (0.50) KMT2AMAPTSMN1; SMN2LMNAKDM4E
SCHEMBL9006438 0.82 GLA (0.50) KMT2AMAPTSMN1; SMN2LMNAKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5489623-A APPLYING POLYMER TO SURFACE, EXPOSING TO INCIDENT PHOTONICRADIATION TO RENDER PORTIONS LESS SOLUBLE OR DISPERSIBLE THE DOW CHEMICAL COMPANY (US) 1996-02-06 US claimed
EP-0676062-A1 PHOTODEFINABLE POLYMERS CONTAINING PERFLUOROCYCLOBUTANE GROUPS THE DOW CHEMICAL COMPANY (US) 1995-10-11 EP claimed
US-5426164-A Solvent and chemical resistant coatings and photoresists; photocuring of perfluorovinyl polymers containing photo active sites; cyclization THE DOW CHEMICAL COMPANY (US) 1995-06-20 US claimed
WO-1994015258-A1 PHOTODEFINABLE POLYMERS CONTAINING PERFLUOROCYCLOBUTANE GROUPS THE DOW CHEMICAL COMPANY (US) 1994-07-07 WO claimed
US-5489623-A APPLYING POLYMER TO SURFACE, EXPOSING TO INCIDENT PHOTONICRADIATION TO RENDER PORTIONS LESS SOLUBLE OR DISPERSIBLE THE DOW CHEMICAL COMPANY (US) 1996-02-06 US disclosed
US-5426164-A Solvent and chemical resistant coatings and photoresists; photocuring of perfluorovinyl polymers containing photo active sites; cyclization THE DOW CHEMICAL COMPANY (US) 1995-06-20 US disclosed