Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARB | P10826 | 20/20 | 0.64 |
| ▸ | RARG | P13631 | 20/20 | 0.64 |
| ▸ | RARA | P10276 | 18/20 | 0.64 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.64 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.64 |
| ▸ | CRABP2 | P29373 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9176637 | 0.90 | RARB (0.64) | RARBRARGRARACYP26A1CYP3A4 | |
| SCHEMBL9180876 | 0.84 | RARB (0.51) | RARBRARGRARACYP26A1CYP3A4 | |
| SCHEMBL8776480 | 0.84 | RARB (0.83) | RARBRARGRARACYP26A1CYP3A4 | |
| SCHEMBL9007075 | 0.83 | RARB (0.49) | RARBRARGRARACYP26A1CYP3A4 | |
| SCHEMBL9488403 | 0.82 | RARB (0.43) | RARBRARGRARACYP26A1CYP3A4 | |
| SCHEMBL9269625 | 0.80 | RXRA (0.65) | RARBRARGRARACYP26A1CYP3A4 | |
| SCHEMBL9007043 | 0.80 | RARB (0.67) | RARBRARGRARACYP26A1CYP3A4 | |
| SCHEMBL29353973 | 0.78 | RARB (1.00) | RARBRARGRARACYP26A1CYP3A4 | |
| SCHEMBL3302926 | 0.78 | RARB (1.00) | RARBRARGRARACYP26A1CYP3A4 | |
| SCHEMBL9187338 | 0.78 | RARB (0.49) | RARBRARGRARACYP26A1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0571546-B1 | CHROMAN AND THIOCHROMANS WITH PHENYLETHYNYL SUBSTITUENTS AT THE 7-POSITION HAVING RETINOID-LIKE BIOLOGICAL ACTIVITY | ALLERGAN INC (US) | 1996-10-16 | — | — | EP | disclosed |
| US-5346915-A | Chromans and thiochromans with phenylethynyl substituents at the 7-position having retinold-like biological activity | ALLERGAN, INC. (US) | 1994-09-13 | — | — | US | disclosed |
| EP-0571546-A1 | CHROMAN AND THIOCHROMANS WITH PHENYLETHYNYL SUBSTITUENTS AT THE 7-POSITION HAVING RETINOID-LIKE BIOLOGICAL ACTIVITY. | ALLERGAN INC (US) | 1993-12-01 | — | — | EP | disclosed |
| WO-1992014725-A1 | CHROMAN AND THIOCHROMANS WITH PHENYLETHYNYL SUBSTITUENTS AT THE 7-POSITION HAVING RETINOID-LIKE BIOLOGICAL ACTIVITY | ALLERGAN, INC. (US) | 1992-09-03 | — | — | WO | disclosed |