Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 2/20 | 0.41 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.35 |
| ▸ | NQO1 | P15559 | 1/20 | 0.34 |
| ▸ | RXRA | P19793 | 1/20 | 0.33 |
| ▸ | RXRB | P28702 | 1/20 | 0.33 |
| ▸ | RXRG | P48443 | 1/20 | 0.33 |
| ▸ | PDE3B | Q13370 | 3/20 | 0.33 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.33 |
| ▸ | THRA | P10827 | 2/20 | 0.32 |
| ▸ | THRB | P10828 | 2/20 | 0.32 |
| ▸ | HPD | P32754 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9007525 | 0.86 | AKR1B1 (0.41) | AKR1B1RXRARXRBRXRGPDE3B | |
| SCHEMBL9007576 | 0.84 | MEN1 (0.32) | SLC9A1NQO1MEN1KMT2APOLB | |
| SCHEMBL9007571 | 0.83 | NR1H4 (0.44) | AKR1B1NQO1MEN1KMT2A | |
| SCHEMBL9007494 | 0.82 | NQO1 (0.39) | AKR1B1SLC9A1NQO1PDE3BPDE3A | |
| SCHEMBL9007551 | 0.81 | WDR5 (0.35) | AKR1B1SLC9A1NQO1THRATHRB | |
| SCHEMBL9007566 | 0.81 | AKR1B1 (0.42) | AKR1B1THRATHRB | |
| SCHEMBL9007552 | 0.80 | GAA (0.40) | AKR1B1KMT2ARXFP1POLBKDM4E | |
| SCHEMBL27537426 | 0.77 | AKR1B1 (0.60) | AKR1B1SLC9A1THRATHRBMEN1 | |
| SCHEMBL9007599 | 0.75 | NQO1 (0.30) | NQO1HPD | |
| SCHEMBL9007515 | 0.68 | KMT2A (0.39) | AKR1B1THRATHRBHPDKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5482968-A | ENZYME INHIBITORS, HYPOGLYCEMIC AGENTS AND VASCULAR AGENTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1996-01-09 | — | — | US | claimed |
| US-5399588-A | Diabetes treatment | AMERICAN HOME PRODUCTS CORPORATION (US) | 1995-03-21 | — | — | US | claimed |
| US-5482968-A | ENZYME INHIBITORS, HYPOGLYCEMIC AGENTS AND VASCULAR AGENTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1996-01-09 | — | — | US | disclosed |
| US-5399588-A | Diabetes treatment | AMERICAN HOME PRODUCTS CORPORATION (US) | 1995-03-21 | — | — | US | disclosed |