Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.44 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.41 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.40 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.40 |
| ▸ | PTGFR | P43088 | 1/20 | 0.40 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.40 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.40 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.40 |
| ▸ | NQO1 | P15559 | 2/20 | 0.40 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.39 |
| ▸ | SLC13A5 | Q86YT5 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9007517 | 0.83 | AKR1B1 (0.41) | AKR1B1NQO1MEN1KMT2A | |
| SCHEMBL9007525 | 0.83 | AKR1B1 (0.41) | AKR1B1PTGDR2 | |
| SCHEMBL9007533 | 0.79 | PTPN7 (0.49) | CYP1A2PTGDR2TBXA2RPTGER4PTGFR | |
| SCHEMBL9007552 | 0.77 | GAA (0.40) | AKR1B1PTGDR2ALDH1A1LMNAKMT2A | |
| SCHEMBL8829522 | 0.75 | ALOX5 (0.45) | CYP1A2TBXA2RPTGER4PTGFRPTGER3 | |
| SCHEMBL9007498 | 0.74 | PTPN7 (0.50) | CYP1A2PTGDR2TBXA2RPTGER4PTGFR | |
| SCHEMBL6238367 | 0.74 | NR1H4 (0.63) | NR1H4AKR1B1CYP1A2PTGDR2TBXA2R | |
| 2-Naphthylacetic Acid SCHEMBL28641469 | 0.73 | NR1H4 (0.71) | NR1H4AKR1B1CYP1A2SLC13A5MEN1 | |
| 2-Naphthylacetic Acid SCHEMBL238445 | 0.73 | NR1H4 (0.71) | NR1H4AKR1B1CYP1A2SLC13A5MEN1 | |
| 2-Naphthylacetic Acid SCHEMBL29366514 | 0.73 | NR1H4 (0.71) | NR1H4AKR1B1CYP1A2SLC13A5MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5482968-A | ENZYME INHIBITORS, HYPOGLYCEMIC AGENTS AND VASCULAR AGENTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1996-01-09 | — | — | US | claimed |
| US-5399588-A | Diabetes treatment | AMERICAN HOME PRODUCTS CORPORATION (US) | 1995-03-21 | — | — | US | claimed |
| US-5482968-A | ENZYME INHIBITORS, HYPOGLYCEMIC AGENTS AND VASCULAR AGENTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1996-01-09 | — | — | US | disclosed |
| US-5399588-A | Diabetes treatment | AMERICAN HOME PRODUCTS CORPORATION (US) | 1995-03-21 | — | — | US | disclosed |