Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 2/20 | 0.41 |
| ▸ | THRA | P10827 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | SLC22A12 | Q96S37 | 9/20 | 0.36 |
| ▸ | LDHA | P00338 | 1/20 | 0.35 |
| ▸ | F10 | P00742 | 1/20 | 0.34 |
| ▸ | RXRA | P19793 | 1/20 | 0.33 |
| ▸ | RXRB | P28702 | 1/20 | 0.33 |
| ▸ | RXRG | P48443 | 1/20 | 0.33 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.33 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9007566 | 0.94 | AKR1B1 (0.42) | AKR1B1THRATHRBSLC22A12LDHA | |
| SCHEMBL9007517 | 0.86 | AKR1B1 (0.41) | AKR1B1THRATHRBRXRARXRB | |
| SCHEMBL9007571 | 0.83 | NR1H4 (0.44) | AKR1B1PTGDR2 | |
| SCHEMBL9007553 | 0.82 | NQO1 (0.37) | AKR1B1THRATHRBF10 | |
| SCHEMBL9007515 | 0.81 | KMT2A (0.39) | AKR1B1THRATHRBSLC22A12 | |
| SCHEMBL9007535 | 0.78 | LDHA (0.32) | AKR1B1LDHA | |
| SCHEMBL9007582 | 0.78 | KMT2A (0.40) | AKR1B1THRATHRBSLC22A12 | |
| SCHEMBL11740657 | 0.77 | AKR1B1 (0.60) | AKR1B1THRATHRBSLC22A12CA2 | |
| SCHEMBL9007552 | 0.75 | GAA (0.40) | AKR1B1PTGDR2 | |
| SCHEMBL9007576 | 0.71 | MEN1 (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5482968-A | ENZYME INHIBITORS, HYPOGLYCEMIC AGENTS AND VASCULAR AGENTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1996-01-09 | — | — | US | claimed |
| US-5399588-A | Diabetes treatment | AMERICAN HOME PRODUCTS CORPORATION (US) | 1995-03-21 | — | — | US | claimed |
| US-5482968-A | ENZYME INHIBITORS, HYPOGLYCEMIC AGENTS AND VASCULAR AGENTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1996-01-09 | — | — | US | disclosed |
| US-5399588-A | Diabetes treatment | AMERICAN HOME PRODUCTS CORPORATION (US) | 1995-03-21 | — | — | US | disclosed |