Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NQO1 | P15559 | 5/20 | 0.39 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | HPD | P32754 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | MAPT | P10636 | 3/20 | 0.32 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.32 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 2/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | APEX1 | P27695 | 1/20 | 0.31 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9007553 | 0.85 | NQO1 (0.37) | NQO1HPDLMNAAKR1B1ALDH1A1 | |
| SCHEMBL9007517 | 0.82 | AKR1B1 (0.41) | NQO1SLC9A1KDM4EHSD17B10HPD | |
| SCHEMBL9007551 | 0.79 | WDR5 (0.35) | NQO1SLC9A1KDM4EHSD17B10HPD | |
| SCHEMBL9007576 | 0.76 | MEN1 (0.32) | NQO1SLC9A1ALDH1A1MAPTPOLB | |
| SCHEMBL9007599 | 0.76 | NQO1 (0.30) | NQO1HPD | |
| SCHEMBL8829522 | 0.74 | ALOX5 (0.45) | NQO1 | |
| SCHEMBL12457724 | 0.73 | LMNA (0.48) | NQO1KDM4EHSD17B10LMNAALDH1A1 | |
| SCHEMBL15352105 | 0.69 | SLC9A1 (0.44) | SLC9A1KDM4EAKR1B1TDP1 | |
| SCHEMBL7221961 | 0.69 | SLC9A1 (0.44) | SLC9A1AKR1B1PKM | |
| SCHEMBL31459979 | 0.69 | SLC9A1 (0.44) | SLC9A1AKR1B1PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5482968-A | ENZYME INHIBITORS, HYPOGLYCEMIC AGENTS AND VASCULAR AGENTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1996-01-09 | — | — | US | disclosed |
| US-5399588-A | Diabetes treatment | AMERICAN HOME PRODUCTS CORPORATION (US) | 1995-03-21 | — | — | US | disclosed |