SCHEMBL9008249

SCHEMBL9008249

Cc1cc(O)c(C(C)(C)C)cc1Sc1cc(C(C)(C)C)c(OP(O)O)cc1C

nearest known ligand 0.69

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALOX15 P16050 5/20 0.69
ALDH1A1 P00352 4/20 0.69
TP53 P04637 3/20 0.69
CYP3A4 P08684 2/20 0.69
SMN1; SMN2 Q16637 2/20 0.69
TSHR P16473 1/20 0.69
MAPK1 P28482 1/20 0.69
HIF1A Q16665 1/20 0.69
TDP1 Q9NUW8 1/20 0.69
LMNA P02545 2/20 0.41
HPGD P15428 1/20 0.41
CYP1A2 P05177 2/20 0.39
KDM4E B2RXH2 1/20 0.39
MAPT P10636 1/20 0.39
ATP2A2 P16615 1/20 0.39
ATP2A3 Q93084 1/20 0.39
CYP2C9 P11712 3/20 0.35
CYP2C19 P33261 2/20 0.35
CYP2D6 P10635 1/20 0.35
NR1I2 O75469 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11066924 0.93 TP53 (0.54) ALOX15ALDH1A1TP53CYP3A4SMN1; SMN2
SCHEMBL29990451 0.90 ALOX15 (0.71) ALOX15ALDH1A1TP53CYP3A4SMN1; SMN2
SCHEMBL1851191 0.90 ALOX15 (0.71) ALOX15ALDH1A1TP53CYP3A4SMN1; SMN2
SCHEMBL9668266 0.85 ALOX15 (0.89) ALOX15ALDH1A1TP53CYP3A4SMN1; SMN2
SCHEMBL3663625 0.85 ALOX15 (0.89) ALOX15ALDH1A1TP53CYP3A4SMN1; SMN2
SCHEMBL31295681 0.83 ALOX15 (1.00) ALOX15ALDH1A1TP53CYP3A4SMN1; SMN2
SCHEMBL29366086 0.83 ALOX15 (1.00) ALOX15ALDH1A1TP53CYP3A4SMN1; SMN2
SCHEMBL39505 0.83 ALOX15 (1.00) ALOX15ALDH1A1TP53CYP3A4SMN1; SMN2
SCHEMBL9375969 0.82 ALOX15 (0.56) ALOX15ALDH1A1TP53CYP3A4SMN1; SMN2
SCHEMBL23331913 0.82 ALDH1A1 (0.73) ALOX15ALDH1A1TP53CYP3A4SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0331095-B1 Improving stability at moderate temperatures of motor vehicle components shaped from polyvinyl chloride resin compositions WITCO CORP (US) 1996-10-09 EP disclosed
US-4950704-A DIKETONE AS HEAT STABILIZER ARGUS CHEMICAL CORPORATION (US) 1990-08-21 US disclosed
EP-0331095-A1 Improving stability at moderate temperatures of motor vehicle components shaped from polyvinyl chloride resin compositions WITCO CORPORATION (US) 1989-09-06 EP disclosed
US-4396735-A N-HETEROCYCLIC COMPOUND AND A HETEROCYCLIC ACID HYDRAZIDE ADEKA ARGUS CHEMICAL CO., LTD. (JP) 1983-08-02 US disclosed
EP-0046161-A2 Stabilized Polyvinylhalide resin PHOENIX CHEMICAL CORPORATION (US) 1982-02-24 EP disclosed
EP-0024919-A2 Process for providing monovalent and polyvalent metal, particularly antimony, mercaptocarboxylic acid ester salts; monovalent and polyvalent metal mercaptocarboxylic acid salts; polyol mercaptocarboxylic acid monoesters, and esters of such polyol mercaptocarboxylic acid esters with a mercaptocarboxylic acid; stabilizer compositions for polyvinyl chloride resins comprising such compounds; and polyvinyl chloride resin compositions comprising a stabilizing amount of such compounds Mack, Gerry (US) 1981-03-11 EP disclosed
US-4222931-A Stabilizers for synthetic polymers comprising 2,2,6,6-tetramethyl-4-piperidyl ether alcohol or ether, phosphonic acid ester and phenolic antioxidant ARGUS CHEMICAL CORPORATION (US) 1980-09-16 US disclosed
US-4210577-A Stabilizers for synthetic polymers comprising 2,2,6,6-tetramethyl-4-piperidyl carboxylic acid ester, phosphonic acid ester and phenol ARGUS CHEMICAL CORPORATION (US) 1980-07-01 US disclosed
US-4209431-A OXIDATION AND HEAT RESISTANCE WITCO CHEMICAL CORPORATION (US) 1980-06-24 US disclosed
US-4110306-A Stabilizers for synthetic polymers comprising 2,2,6,6-tetramethyl-4-piperidyl carboxylic acid ester, a triphosphite, and an acid phosphite or salt thereof ARGUS CHEMICAL CORPORATION (US) 1978-08-29 US disclosed
US-4105627-A MERCAPTOHETEROCYCLIC RESIN STABILIZERS ARGUS CHEMICAL CORPORATION (US) 1978-08-08 US disclosed
US-4080364-A Stabilization of polyolefins against degradative deterioration as a result of exposure to light and air at elevated temperatures ARGUS CHEMICAL CORPORATION (US) 1978-03-21 US disclosed
US-3997551-A OXIDATION RESISTANCE, STABILIZE POLYMERS ARGUS CHEMICAL CORPORATION (US) 1976-12-14 US disclosed