Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 4/20 | 0.52 |
| ▸ | GNAI3 | P08754 | 3/20 | 0.47 |
| ▸ | GNAO1 | P09471 | 3/20 | 0.47 |
| ▸ | GNAI1 | P63096 | 3/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 2/20 | 0.37 |
| ▸ | DRD2 | P14416 | 2/20 | 0.37 |
| ▸ | DRD3 | P35462 | 2/20 | 0.37 |
| ▸ | SMYD3 | Q9H7B4 | 3/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.35 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23169461 | 0.81 | PKM (0.50) | EPHX1EPHX2 | |
| SCHEMBL1596519 | 0.81 | EPHX1 (0.59) | EPHX1GNAI3GNAO1GNAI1POLB | |
| SCHEMBL22722016 | 0.77 | HTR1A (0.36) | POLBEPHX2HTR1ADRD2DRD3 | |
| Hydrochloric Acid SCHEMBL27679507 | 0.77 | EPHX1 (0.50) | EPHX1GNAI3GNAO1GNAI1POLB | |
| SCHEMBL12436799 | 0.77 | HTR1A (0.36) | POLBEPHX2HTR1ADRD2DRD3 | |
| SCHEMBL1315538 | 0.76 | EPHX1 (0.51) | EPHX1EPHX2SIGMAR1CHRM5CHRM3 | |
| SCHEMBL27589350 | 0.76 | NPC1 (0.50) | EPHX1 | |
| SCHEMBL24790610 | 0.75 | EPHX1 (0.55) | EPHX1GNAI3GNAO1GNAI1POLB | |
| SCHEMBL18950691 | 0.75 | DRD2 (0.47) | HTR1ADRD2DRD3KCNH2HTR2A | |
| SCHEMBL18950688 | 0.75 | DRD2 (0.47) | HTR1ADRD2DRD3KCNH2HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5576333-A | ASTHMA TREATMENT | ZENECA LIMITED (GB) | 1996-11-19 | — | — | US | disclosed |
| US-5559131-A | ANTAGONISTS OF TACHYKININS AT THE NEUROKININ 2 RECEPTOR, ANTIASTHMA | ZENECA LIMITED (GB) | 1996-09-24 | — | — | US | disclosed |
| US-5559132-A | ANTAGONIST OF TACHYKININS AT THE NEUROKININ 2 RECEPTOR, ANTIASTHMA | ZENECA LIMITED (GB) | 1996-09-24 | — | — | US | disclosed |
| EP-0667858-A1 | 4-CARBOXOAMIDO PIPERIDINE DERIVATIVES, INTERMEDIATES AND USE AS NEUROKININ ANTAGONISTS | ZENECA LIMITED (GB) | 1995-08-23 | — | — | EP | disclosed |
| WO-1994010146-A1 | 4-CARBOXOAMIDO PIPERIDINE DERIVATIVES, INTERMEDIATES AND USE AS NEUROKININ ANTAGONISTS | ZENECA LIMITED (GB) | 1994-05-11 | — | — | WO | disclosed |