Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.37 |
| ▸ | IDO1 | P14902 | 2/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.31 |
| ▸ | HTR2C | P28335 | 1/20 | 0.31 |
| ▸ | HTR2B | P41595 | 1/20 | 0.31 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.31 |
| ▸ | CTSS | P25774 | 1/20 | 0.31 |
| ▸ | CTSK | P43235 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9566318 | 0.92 | TAAR1 (0.39) | TAAR1IDO1RIPK1CTSSCTSK | |
| SCHEMBL9566221 | 0.85 | TAAR1 (0.41) | TAAR1IDO1HTR2AHTR2CHTR2B | |
| SCHEMBL30667522 | 0.85 | TAAR1 (0.41) | TAAR1IDO1HTR2AHTR2CHTR2B | |
| SCHEMBL9009571 | 0.83 | — | — | |
| SCHEMBL5378118 | 0.82 | ADAMTS4 (0.33) | — | |
| SCHEMBL9566191 | 0.78 | TAAR1 (0.37) | TAAR1IDO1RIPK1CTSSCTSK | |
| SCHEMBL9718099 | 0.77 | TAAR1 (0.36) | TAAR1IDO1HTR2AHTR2CHTR2B | |
| SCHEMBL6347925 | 0.76 | TAAR1 (0.43) | TAAR1IDO1RIPK1TSHR | |
| SCHEMBL30271106 | 0.76 | TAAR1 (0.43) | TAAR1IDO1RIPK1TSHR | |
| SCHEMBL9566323 | 0.76 | SIGMAR1 (0.40) | TAAR1IDO1HTR2AHTR2CHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5550248-A | Substituted stryl heterocyclic amido prostaglandin analogs | E.R. SQUIBB & SONS, INC. (US) | 1996-08-27 | — | — | US | disclosed |
| EP-0447188-B1 | 7-Oxabicycloheptane imidazole prostaglandin analogs useful in the treatment of thrombotic and vasospastic diseases | SQUIBB & SONS INC (US) | 1995-06-28 | — | — | EP | disclosed |
| EP-0391652-B1 | Interphenylène 7-oxabicycloheptyl substituted heterocyclic amide prostaglandin analogs useful in the treatment of thrombotic and vasopastic disease | SQUIBB & SONS INC (US) | 1995-03-15 | — | — | EP | disclosed |
| US-5290799-A | 7-oxabicycloheptyl substituted heterocyclic thioamide prostaglandin analogs useful in the treatment of thrombotic and vasospastic disease | E. R. SQUIBB & SONS, INC. (US) | 1994-03-01 | — | — | US | disclosed |
| US-5238951-A | Thromboxane receptor antagonist | E. R. SQUIBB & SONS, INC. (US) | 1993-08-24 | — | — | US | disclosed |
| EP-0536713-A1 | Oxazole and imidazole derivatives as prostaglandin analogs | E.R. SQUIBB & SONS, INC. (US) | 1993-04-14 | — | — | EP | disclosed |
| US-5153327-A | 7-Oxabicycloheptyl substituted heterocyclic amide or ester prostaglandin analogs useful in the treatment of thrombotic and vasospastic disease | E. R. SQUIBB & SONS, INC. (US) | 1992-10-06 | — | — | US | disclosed |
| EP-0497629-A1 | Heterocyclic amido prostaglandin analogs | E.R. SQUIBB & SONS, INC. (US) | 1992-08-05 | — | — | EP | disclosed |
| EP-0497085-A1 | Heterocyclic ketone prostaglandin analogs | E.R. SQUIBB & SONS, INC. (US) | 1992-08-05 | — | — | EP | disclosed |
| US-5135939-A | HETEROCYCLIC KETONE PROSTAGLANDIN ANALOGS | E. R. SQUIBB & SONS, INC. (US) | 1992-08-04 | — | — | US | disclosed |
| US-5126370-A | Anti-thrombotic heterocyclic amido prostaglandin analogs | E. R. SQUIBB & SONS, INC. (US) | 1992-06-30 | — | — | US | disclosed |
| US-5100889-A | Thromboxane A2 receptor antagonists, thromboxane synthetase inhibitor | E. R. SQUIBB & SONS, INC. (US) | 1992-03-31 | — | — | US | disclosed |
| EP-0476994-A1 | 7-Oxabicycloheptyl substituted heterocyclic thioamide prostaglandin analogs useful in the treatment of thrombotic and vasospastic disease | E.R. SQUIBB & SONS, INC. (US) | 1992-03-25 | — | — | EP | disclosed |
| EP-0447188-A2 | 7-Oxabicycloheptane imidazole prostaglandin analogs useful in the treatment of thrombotic and vasospastic diseases | E.R. SQUIBB & SONS, INC. (US) | 1991-09-18 | — | — | EP | disclosed |
| US-4977174-A | Anticoagulants, antischemic agents | E. R. SQUIBB & SONS, INC. (US) | 1990-12-11 | — | — | US | disclosed |
| EP-0391652-A1 | Interphenylène 7-oxabicycloheptyl substituted heterocyclic amide prostaglandin analogs useful in the treatment of thrombotic and vasopastic disease | E.R. SQUIBB & SONS, INC. (US) | 1990-10-10 | — | — | EP | disclosed |