Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RHEB | Q15382 | 3/20 | 0.50 |
| ▸ | CHEK2 | O96017 | 4/20 | 0.49 |
| ▸ | TRPV1 | Q8NER1 | 4/20 | 0.48 |
| ▸ | MMP2 | P08253 | 3/20 | 0.48 |
| ▸ | MMP9 | P14780 | 3/20 | 0.48 |
| ▸ | MMP8 | P22894 | 3/20 | 0.48 |
| ▸ | MMP13 | P45452 | 3/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.45 |
| ▸ | DGAT1 | O75907 | 2/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.45 |
| ▸ | NPBWR1 | P48145 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10326101 | 0.85 | KDM4E (0.51) | TRPV1MMP2MMP9MMP8MMP13 | |
| SCHEMBL25206796 | 0.84 | RHEB (0.69) | RHEBCHEK2MMP2MMP9MMP8 | |
| SCHEMBL19137955 | 0.83 | TRPV1 (0.55) | RHEBCHEK2TRPV1DGAT1KCNH2 | |
| SCHEMBL16121405 | 0.81 | CHEK2 (0.47) | RHEBCHEK2TRPV1DGAT1KCNH2 | |
| SCHEMBL19137958 | 0.80 | DGAT1 (0.53) | RHEBCHEK2DGAT1KCNH2NPBWR1 | |
| SCHEMBL19137928 | 0.79 | DGAT1 (0.52) | RHEBCHEK2DGAT1KCNH2NPBWR1 | |
| SCHEMBL19137962 | 0.78 | DGAT1 (0.67) | CHEK2DGAT1KCNH2 | |
| SCHEMBL24075038 | 0.77 | RHEB (0.68) | RHEBCHEK2TRPV1DGAT1KCNH2 | |
| SCHEMBL10325105 | 0.76 | NPBWR1 (0.58) | TRPV1MMP2MMP9MMP8MMP13 | |
| SCHEMBL900794 | 0.76 | NPBWR1 (0.74) | TRPV1MMP2MMP9MMP8MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012044567-A2 | IMIDAZOLE DERIVATIVES | MERCK SHARP & DOHME CORP. (US) | 2012-04-05 | — | — | WO | disclosed |