Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Sulfuric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.81 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.81 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | ACP1 | P24666 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL103727 | 0.90 | LMNA (1.00) | LMNAPDE10APDPK1ALDH1A1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL2002578 | 0.88 | LMNA (0.96) | LMNAPDE10APDPK1ALDH1A1SMN1; SMN2 | |
| SCHEMBL9722792 | 0.79 | PDPK1 (0.57) | LMNAPDE10APDPK1ALDH1A1SMN1; SMN2 | |
| SCHEMBL8128010 | 0.76 | LMNA (0.71) | LMNAPDE10APDPK1ALDH1A1SMN1; SMN2 | |
| SCHEMBL6707554 | 0.76 | LMNA (0.71) | LMNAPDE10APDPK1ALDH1A1SMN1; SMN2 | |
| SCHEMBL3057415 | 0.75 | LMNA (0.57) | LMNAPDE10AALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL28990422 | 0.75 | LMNA (0.56) | LMNAPDE10AALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL4302032 | 0.73 | PDPK1 (0.59) | LMNAPDE10APDPK1ALDH1A1SMN1; SMN2 | |
| SCHEMBL5670201 | 0.73 | PDPK1 (0.59) | LMNAPDE10APDPK1ALDH1A1SMN1; SMN2 | |
| Bromide SCHEMBL5669202 | 0.72 | PDPK1 (0.57) | LMNAPDE10APDPK1ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0529600-B1 | Process for the preparation of 2-aminobenzothiazoles | HOECHST AG (DE) | 1996-11-06 | — | — | EP | disclosed |
| US-5374737-A | Catalytic cyclization of N-phenyl thiourea derivatives in sulfuric acid with catalytic amount of bromine or bromide | HOECHST AKTIENGESELLSCHAFT (DE) | 1994-12-20 | — | — | US | disclosed |
| EP-0529600-A1 | Process for the preparation of 2-aminobenzothiazoles | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-03-03 | — | — | EP | disclosed |