Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CARM1 | Q86X55 | 1/20 | 0.48 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.48 |
| ▸ | PRMT8 | Q9NR22 | 1/20 | 0.48 |
| ▸ | KARS1 | Q15046 | 2/20 | 0.46 |
| ▸ | VCP | P55072 | 1/20 | 0.44 |
| ▸ | DKK1 | O94907 | 1/20 | 0.44 |
| ▸ | DHFR | P00374 | 8/20 | 0.43 |
| ▸ | PRKCA | P17252 | 1/20 | 0.43 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | HTR7 | P34969 | 1/20 | 0.40 |
| ▸ | AKT1 | P31749 | 3/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | AKT2 | P31751 | 1/20 | 0.39 |
| ▸ | AKT3 | Q9Y243 | 1/20 | 0.39 |
| ▸ | CDK1 | P06493 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL902780 | 0.76 | KARS1 (0.78) | CARM1PRMT6PRMT8KARS1VCP | |
| SCHEMBL3756786 | 0.69 | CARM1 (0.51) | CARM1PRMT6PRMT8KARS1DKK1 | |
| SCHEMBL7008838 | 0.67 | HRH4 (0.48) | KARS1DKK1HRH3AKT2 | |
| SCHEMBL9982790 | 0.67 | ADRB1 (0.59) | VCPDHFRHTR7 | |
| Hydrochloric Acid SCHEMBL16684861 | 0.66 | HRH4 (0.47) | KARS1DKK1HRH3AKT2 | |
| SCHEMBL21590373 | 0.66 | HRH3 (0.53) | VCPDKK1HRH3AKT2CDK1 | |
| SCHEMBL19209929 | 0.65 | DHFR (0.72) | DHFR | |
| Hydrochloric Acid SCHEMBL3513389 | 0.65 | SMO (0.49) | VCP | |
| SCHEMBL12269941 | 0.65 | CAMK2D (0.47) | CARM1PRMT6PRMT8KARS1DHFR | |
| Hydrochloric Acid SCHEMBL9876690 | 0.65 | ADRB1 (0.56) | VCPDHFRHTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012041476-A1 | PYRIDINE AND ISOQUINOLINE DERIVATIVES AS SYK- AND JAK-KINASE INHIBITORS | ALMIRALL, S.A. (ES) | 2012-04-05 | — | — | WO | disclosed |