Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KARS1 | Q15046 | 12/20 | 0.68 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | SYK | P43405 | 1/20 | 0.48 |
| ▸ | GRM5 | P41594 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2226841 | 0.85 | KARS1 (0.53) | KARS1CLK4CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL902728 | 0.81 | KARS1 (1.00) | KARS1CLK4SYKMAP4K4ABL1 | |
| SCHEMBL1755624 | 0.80 | KARS1 (0.79) | KARS1CLK4SYKKDM4EMAP4K4 | |
| SCHEMBL902672 | 0.79 | KARS1 (0.74) | KARS1CLK4SYKMAP4K4ABL1 | |
| SCHEMBL15344138 | 0.79 | CLK4 (0.56) | CLK4CYP1A2CYP3A4CYP2D6TSHR | |
| SCHEMBL902707 | 0.79 | SYK (0.76) | KARS1CLK4SYKMAP4K4ABL1 | |
| SCHEMBL902781 | 0.78 | KARS1 (1.00) | KARS1CLK4ALDH1A1LMNASYK | |
| SCHEMBL14673942 | 0.77 | KARS1 (0.52) | KARS1CLK4HSD17B10ALDH1A1TP53 | |
| SCHEMBL2228325 | 0.77 | KARS1 (0.52) | KARS1SYKKDR | |
| SCHEMBL13136581 | 0.77 | KARS1 (0.54) | KARS1CLK4SYKMAP4K4ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | disclosed |
| WO-2012041476-A1 | PYRIDINE AND ISOQUINOLINE DERIVATIVES AS SYK- AND JAK-KINASE INHIBITORS | ALMIRALL, S.A. (ES) | 2012-04-05 | — | — | WO | disclosed |