SCHEMBL901281

SCHEMBL901281

COc1cc2nccc(Oc3ccc(N)cc3)c2cc1OC.Nc1ccc(F)cc1

nearest known ligand 0.71

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PDGFRA P16234 5/20 0.68
KDR P35968 4/20 0.68
PDGFRB P09619 1/20 0.65
MET P08581 4/20 0.63
FGFR2 P21802 4/20 0.62
AURKA O14965 1/20 0.61
RIPK2 O43353 1/20 0.61
ABCB11 O95342 1/20 0.61
ABL1 P00519 1/20 0.61
EGFR P00533 1/20 0.61
ERBB2 P04626 1/20 0.61
NTRK1 P04629 1/20 0.61
LCK P06239 1/20 0.61
PGR P06401 1/20 0.61
LYN P07948 1/20 0.61
RET P07949 1/20 0.61
CHRM2 P08172 1/20 0.61
HCK P08631 1/20 0.61
ADRA2A P08913 1/20 0.61
ADORA3 P0DMS8 1/20 0.61

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Fluorobenzene SCHEMBL28724473 0.94 FGFR2 (0.65) PDGFRAKDRPDGFRBMETFGFR2
SCHEMBL167396 0.93 PDGFRA (0.74) PDGFRAKDRPDGFRBFGFR2EGFR
Hydrochloric Acid SCHEMBL23528156 0.92 PDGFRA (0.72) PDGFRAKDRPDGFRBFGFR2EGFR
SCHEMBL282174 0.88 PDGFRA (0.59) PDGFRAKDRPDGFRBMETFGFR2
SCHEMBL4471141 0.86 FGFR2 (0.83) PDGFRAKDRPDGFRBMETFGFR2
SCHEMBL5825496 0.86 PDGFRA (0.67) PDGFRAKDRPDGFRBMETFGFR2
SCHEMBL14540576 0.85 PDGFRA (0.62) PDGFRAKDRPDGFRBFGFR2EGFR
SCHEMBL13980801 0.84 PDGFRA (0.60) PDGFRAKDRPDGFRBFGFR2EGFR
SCHEMBL14139343 0.84 PDGFRA (0.61) PDGFRAKDRPDGFRBFGFR2AXL
SCHEMBL14139303 0.84 PDGFRA (0.61) PDGFRAKDRPDGFRBFGFR2AXL

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 149 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12016854-B2 Liquid dosage forms to treat cancer EXELIXIS, INC. (US) 2024-06-25 US disclosed
US-20240189298-A1 PROCESSES FOR PREPARING QUINOLINE COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING SUCH COMPOUNDS EXELIXIS, INC. 2024-06-13 US disclosed
US-20240156804-A1 C-Met Modulator Pharmaceutical Compositions EXELIXIS, INC. 2024-05-16 US disclosed
US-20240156803-A1 Method of Treating Cancer REGENTS OF THE UNIVERSITY OF MICHIGAN 2024-05-16 US disclosed
US-11969419-B2 Method of treating cancer EXELIXIS, INC. (US) 2024-04-30 US disclosed
CN-117771363-A Carbotinib and alemtuzumab combination for treating cancer 埃克塞里艾克西斯公司 2024-03-29 CN disclosed
CN-117205312-A Carbotinib and alemtuzumab combination for treating cancer 埃克塞里艾克西斯公司 2023-12-12 CN disclosed
CN-117205313-A Carbotinib and alemtuzumab combination for treating cancer 埃克塞里艾克西斯公司 2023-12-12 CN disclosed
US-20230314440-A1 METHOD OF TREATING CANCER EXELIXIS, INC. 2023-10-05 US disclosed
US-20230301980-A1 Method of Treating Cancer EXELIXIS, INC. 2023-09-28 US disclosed
WO-2013043840-A1 METHOD FOR TREATING OSTEOPOROSIS EXELIXIS, INC. (US) 2013-03-28 WO disclosed
EP-2387563-B1 MALATE SALT OF N- (4- { [ 6, 7-BIS (METHYLOXY) QUINOLIN-4-YL]OXY}PHENYL-N' - (4 -FLUOROPHENYL) CYCLOPROPANE-1,1-DICARBOXAMIDE, AND CRYSTALLINE FORMS THEREOF FOR THE TREATMENT OF CANCER EXELIXIS INC (US) 2013-03-06 EP disclosed
US-20120282179-A1 Methods of Using C-Met Modulators EXELIXIS, INC. (US) 2012-11-08 US disclosed
US-20120252840-A1 Method of Treating Cancer EXELIXIS, INC. (US) 2012-10-04 US disclosed
WO-2012109510-A1 PROCESSES FOR PREPARING QUINOLINE COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING SUCH COMPOUNDS EXELIXIS, INC. (US) 2012-08-16 WO disclosed
EP-2461810-A1 METHODS OF USING C-MET MODULATORS Exelixis, Inc. (US) 2012-06-13 EP disclosed
WO-2012044572-A1 DUAL INHIBITORS OF MET AND VEGF FOR THE TREATMENT OF CASTRATION- RESISTANT PROSTATE CANCER AND OSTEOBLASTIC BONE METASTASES EXELIXIS, INC. (US) 2012-04-05 WO disclosed
WO-2012044577-A1 DUAL INHIBITORS OF MET AND VEGF FOR THE TREATMENT OF CASTRATION RESISTANT PROSTATE CANCER AND OSTEOBLASTIC BONE METASTASES EXELIXIS, INC. (US) 2012-04-05 WO disclosed
WO-2012009722-A1 C-MET MODULATOR PHARMACEUTICAL COMPOSITIONS EXELIXIS, INC. (US) 2012-01-19 WO disclosed
WO-2010083414-A1 MALATE SALT OF N- (4- { [ 6, 7-BIS (METHYLOXY) QUIN0LIN-4-YL] OXY}PHENYL-N' - (4 -FLUOROPHENYL) CYCLOPROPANE-1-DICARBOXAMIDE, AND CRYSTALLINE FORMS THEROF FOR THE TREATMENT OF CANCER EXELIXIS, INC. (US) 2010-07-22 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11969419-B2 Method of treating cancer MET, HGF, ACP3 PDGFRA 109/4885KDR 8/4885PDGFRB 70/4885
US-20240156803-A1 Method of Treating Cancer MET, HGF, ACP3 PDGFRA 109/4885KDR 8/4885PDGFRB 70/4885
US-20230301980-A1 Method of Treating Cancer MET, HGF, ACP3 PDGFRA 109/4885KDR 8/4885PDGFRB 70/4885
US-20240156804-A1 C-Met Modulator Pharmaceutical Compositions MET, HGFAC, HGF PDGFRA 143/4885KDR 191/4885PDGFRB 39/4885
US-20240189298-A1 PROCESSES FOR PREPARING QUINOLINE COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING SUCH COMPOUNDS HAX1, HRH1, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16 PDGFRA 3965/4885KDR 4574/4885PDGFRB 3177/4885
US-20120282179-A1 Methods of Using C-Met Modulators MET, KRAS, HGF PDGFRA 174/4885KDR 157/4885PDGFRB 84/4885
US-20120252840-A1 Method of Treating Cancer MET, FLT1, TIE1 PDGFRA 209/4885KDR 4/4885PDGFRB 191/4885
US-12016854-B2 Liquid dosage forms to treat cancer FGFR3, KRAS, TP53 PDGFRA 299/4885KDR 164/4885PDGFRB 152/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.