Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.56 |
| ▸ | XDH | P47989 | 1/20 | 0.56 |
| ▸ | IDO1 | P14902 | 2/20 | 0.51 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.51 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.51 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.50 |
| ▸ | CDC7 | O00311 | 1/20 | 0.48 |
| ▸ | CDK2 | P24941 | 1/20 | 0.48 |
| ▸ | CTSS | P25774 | 1/20 | 0.48 |
| ▸ | CTSK | P43235 | 1/20 | 0.48 |
| ▸ | ATR | Q13535 | 1/20 | 0.47 |
| ▸ | GRM5 | P41594 | 2/20 | 0.47 |
| ▸ | KDM1A | O60341 | 1/20 | 0.46 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10431256 | 0.82 | GABRA1 (0.59) | XDHIDO1ADORA2AADORA1CLK4 | |
| SCHEMBL18105512 | 0.82 | ASIC3 (0.60) | ASIC3ADORA2ACDC7CDK2 | |
| SCHEMBL20416722 | 0.81 | XDH (0.55) | XDHIDO1ADORA2AADORA1CLK4 | |
| SCHEMBL31186635 | 0.81 | XDH (0.55) | XDHIDO1ADORA2AADORA1CLK4 | |
| SCHEMBL9792980 | 0.81 | CTSS (0.62) | XDHIDO1ADORA2AADORA1CLK4 | |
| SCHEMBL20417087 | 0.80 | XDH (0.53) | XDHIDO1ADORA2AADORA1CLK4 | |
| SCHEMBL3266995 | 0.79 | IDO1 (0.51) | XDHIDO1ADORA2ACLK4CTSS | |
| SCHEMBL23662309 | 0.79 | ADORA2A (0.57) | XDHIDO1ADORA2AADORA1CLK4 | |
| SCHEMBL20632489 | 0.78 | XDH (0.51) | XDHIDO1ADORA2AADORA1CLK4 | |
| SCHEMBL19471325 | 0.77 | XDH (0.65) | XDHIDO1ADORA2AADORA1CLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | disclosed |
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | disclosed |
| WO-2012041476-A1 | PYRIDINE AND ISOQUINOLINE DERIVATIVES AS SYK- AND JAK-KINASE INHIBITORS | ALMIRALL, S.A. (ES) | 2012-04-05 | — | — | WO | disclosed |
| WO-2012041476-A1 | PYRIDINE AND ISOQUINOLINE DERIVATIVES AS SYK- AND JAK-KINASE INHIBITORS | ALMIRALL, S.A. (ES) | 2012-04-05 | — | — | WO | disclosed |
| WO-2011136483-A1 | NOVEL COMPOUNDS FOR ORGANIC ELECTRONIC MATERIAL AND ORGANIC ELECTROLUMINESCENT DEVICE USING THE SAME | ROHM AND HAAS ELECTRONIC MATERIALS KOREA LTD. (KR) | 2011-11-03 | — | — | WO | disclosed |