Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | TYK2 | P29597 | 2/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | JAK1 | P23458 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL902713 | 0.89 | CHEK1 (0.39) | RAB9AKMT2ACHEK1MEN1POLB | |
| SCHEMBL901297 | 0.86 | KMT2A (0.44) | RAB9AKMT2ACHEK1MEN1POLB | |
| SCHEMBL10086656 | 0.76 | ALDH1A1 (0.57) | KMT2AMEN1TYK2JAK2JAK1 | |
| SCHEMBL569249 | 0.75 | ALDH1A1 (0.59) | KMT2AMEN1POLBKDM4EHTT | |
| SCHEMBL1368376 | 0.75 | JAK2 (0.61) | RAB9AKMT2ATYK2JAK2JAK1 | |
| SCHEMBL1368373 | 0.75 | JAK2 (0.61) | RAB9AKMT2ATYK2JAK2JAK1 | |
| SCHEMBL3715743 | 0.75 | ALDH1A1 (0.50) | KMT2AMEN1POLBKDM4EHTT | |
| SCHEMBL647152 | 0.74 | ROCK1 (0.58) | RAB9AKMT2AMEN1POLBKDM4E | |
| Hydrochloric Acid SCHEMBL29890892 | 0.74 | ALDH1A1 (0.57) | KMT2AMEN1POLBKDM4EHTT | |
| SCHEMBL10269158 | 0.74 | KARS1 (0.46) | RAB9AKMT2ACHEK1MEN1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | disclosed |
| WO-2012041476-A1 | PYRIDINE AND ISOQUINOLINE DERIVATIVES AS SYK- AND JAK-KINASE INHIBITORS | ALMIRALL, S.A. (ES) | 2012-04-05 | — | — | WO | disclosed |