Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | DRD2 | P14416 | 2/20 | 0.46 |
| ▸ | DRD4 | P21917 | 2/20 | 0.46 |
| ▸ | DRD3 | P35462 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.43 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9013385 | 0.96 | MEN1 (0.47) | KMT2AMEN1TDP1ACHE | |
| SCHEMBL9013689 | 0.95 | ACHE (0.47) | KMT2AMEN1DRD2DRD4DRD3 | |
| SCHEMBL9013654 | 0.94 | KMT2A (0.50) | KMT2AMEN1TDP1ALOX5ALDH1A1 | |
| SCHEMBL9013760 | 0.92 | CYP2D6 (0.48) | KMT2AMEN1TDP1ALOX5ALDH1A1 | |
| SCHEMBL9013570 | 0.91 | ACHE (0.44) | KMT2AMEN1DRD2DRD4DRD3 | |
| SCHEMBL9013352 | 0.90 | MEN1 (0.52) | KMT2AMEN1TDP1ALOX5ALDH1A1 | |
| SCHEMBL9013419 | 0.89 | ESR1 (0.45) | KMT2AMEN1DRD2DRD4DRD3 | |
| SCHEMBL9013741 | 0.87 | MEN1 (0.50) | KMT2AMEN1DRD2DRD4DRD3 | |
| SCHEMBL9013766 | 0.83 | MEN1 (0.47) | KMT2AMEN1 | |
| SCHEMBL9013518 | 0.83 | CYP2D6 (0.46) | KMT2AMEN1ALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5589477-A | LEARNING ENHANCEMENT, CNS | NIPPON SHINYAKU COMPANY, LIMITED (JP) | 1996-12-31 | — | — | US | disclosed |
| EP-0555478-A1 | PYRIMIDINE DERIVATIVE AND MEDICINE | NIPPON SHINYAKU COMPANY, LIMITED (JP) | 1993-08-18 | — | — | EP | disclosed |