Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KARS1 | Q15046 | 11/20 | 0.44 |
| ▸ | CDK9 | P50750 | 3/20 | 0.36 |
| ▸ | NAMPT | P43490 | 1/20 | 0.35 |
| ▸ | WNT3A | P56704 | 1/20 | 0.34 |
| ▸ | LNPEP | Q9UIQ6 | 1/20 | 0.34 |
| ▸ | PPARG | P37231 | 1/20 | 0.33 |
| ▸ | PPARA | Q07869 | 1/20 | 0.33 |
| ▸ | BTK | Q06187 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1704897 | 0.93 | KARS1 (0.42) | KARS1NAMPTWNT3ALNPEP | |
| SCHEMBL902876 | 0.87 | KARS1 (0.43) | KARS1NAMPTWNT3A | |
| SCHEMBL902874 | 0.87 | KARS1 (0.43) | KARS1NAMPTWNT3A | |
| SCHEMBL902144 | 0.84 | KARS1 (0.59) | KARS1 | |
| SCHEMBL901769 | 0.82 | KARS1 (0.60) | KARS1NAMPT | |
| SCHEMBL901948 | 0.80 | KARS1 (0.46) | KARS1CDK9NAMPT | |
| SCHEMBL1755672 | 0.80 | KARS1 (0.49) | KARS1CDK9WNT3A | |
| SCHEMBL1704353 | 0.78 | KARS1 (0.55) | KARS1WNT3A | |
| SCHEMBL1704842 | 0.77 | KARS1 (0.52) | KARS1CDK9NAMPT | |
| SCHEMBL1704307 | 0.77 | KARS1 (0.49) | KARS1NAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | disclosed |
| WO-2012041476-A1 | PYRIDINE AND ISOQUINOLINE DERIVATIVES AS SYK- AND JAK-KINASE INHIBITORS | ALMIRALL, S.A. (ES) | 2012-04-05 | — | — | WO | disclosed |