Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNT1 | Q5JUK3 | 1/20 | 0.66 |
| ▸ | MC5R | P33032 | 2/20 | 0.65 |
| ▸ | MC1R | Q01726 | 2/20 | 0.65 |
| ▸ | ECE1 | P42892 | 3/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | MPO | P05164 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | BLM | P54132 | 1/20 | 0.56 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.56 |
| ▸ | BRS3 | P32247 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27923213 | 1.00 | KCNT1 (0.66) | KCNT1MC5RMC1RECE1KDM4E | |
| Trifluoroacetic Acid SCHEMBL13723646 | 0.93 | KCNT1 (0.59) | KCNT1MC5RMC1RECE1MAPT | |
| Trifluoroacetic Acid SCHEMBL27959205 | 0.93 | KCNT1 (0.59) | KCNT1MC5RMC1RECE1MAPT | |
| Trifluoroacetic Acid SCHEMBL27941817 | 0.91 | KCNT1 (0.57) | KCNT1MC5RMC1RECE1KDM4E | |
| Trifluoroacetic Acid SCHEMBL15284580 | 0.91 | KCNT1 (0.57) | KCNT1MC5RMC1RECE1KDM4E | |
| SCHEMBL29810269 | 0.90 | KCNT1 (0.69) | KCNT1KDM4EMEN1LMNAMPO | |
| SCHEMBL9583736 | 0.90 | KCNT1 (0.69) | KCNT1KDM4EMEN1LMNAMPO | |
| SCHEMBL8705016 | 0.90 | KCNT1 (0.69) | KCNT1KDM4EMEN1LMNAMPO | |
| SCHEMBL900917 | 0.90 | KCNT1 (0.69) | KCNT1KDM4EMEN1LMNAMPO | |
| SCHEMBL29459408 | 0.86 | MC5R (0.84) | KCNT1MC5RMC1RECE1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2621508-B1 | N-CARBOXYALKYL AURISTATINS AND THE USE THEREOF | SEATTLE GENETICS INC (US) | 2015-08-26 | — | — | EP | disclosed |
| US-20150148298-A1 | N-CARBOXYALKYL-AURISTATIN AND USE THEREOF | SEATTLE GENETICS, INC. (US) | 2015-05-28 | — | — | US | disclosed |
| US-8987209-B2 | N-carboxyalkyl-auristatin and the use thereof | SEATTLE GENETICS, INC. (US) | 2015-03-24 | — | — | US | disclosed |
| US-20130261064-A1 | N-CARBOXYALKYL-AURISTATIN AND THE USE THEREOF | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2013-10-03 | — | — | US | disclosed |
| EP-2621508-A1 | N-CARBOXYALKYL AURISTATINS AND THE USE THEREOF | Seattle Genetics, Inc. (US) | 2013-08-07 | — | — | EP | disclosed |
| WO-2012041805-A1 | N-CARBOXYALKYL AURISTATINS AND THE USE THEREOF | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2012-04-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130261064-A1 | N-CARBOXYALKYL-AURISTATIN AND THE USE THEREOF | HDGF, HGF, HGFAC | KCNT1 3176/4885MC5R 853/4885MC1R 833/4885 |
| US-20150148298-A1 | N-CARBOXYALKYL-AURISTATIN AND USE THEREOF | HDGF, HGFAC, HGF | KCNT1 2832/4885MC5R 895/4885MC1R 898/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.