Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 4/20 | 0.57 |
| ▸ | DRD2 | P14416 | 3/20 | 0.39 |
| ▸ | DRD4 | P21917 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | CCR2 | P41597 | 1/20 | 0.39 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9014406 | 0.82 | KCNH2 (0.83) | KCNH2DRD2DRD4 | |
| SCHEMBL9014422 | 0.80 | FFAR1 (0.48) | KCNH2FFAR1 | |
| SCHEMBL9014380 | 0.79 | KCNH2 (0.48) | KCNH2DRD2DRD4SLC6A4MEN1 | |
| SCHEMBL9014298 | 0.78 | SIGMAR1 (0.48) | KCNH2SIGMAR1 | |
| Bromide SCHEMBL10407846 | 0.74 | KCNH2 (0.68) | KCNH2DRD2DRD4SLC6A4SIGMAR1 | |
| Hydrochloric Acid SCHEMBL10408435 | 0.73 | KCNH2 (0.68) | KCNH2DRD2MEN1KMT2ASIGMAR1 | |
| SCHEMBL6792592 | 0.73 | DRD2 (0.52) | KCNH2DRD2DRD4SLC6A4MEN1 | |
| SCHEMBL10407767 | 0.73 | KCNH2 (0.67) | KCNH2DRD2DRD4SLC6A4SIGMAR1 | |
| Terikalant SCHEMBL30770792 | 0.72 | KCNH2 (1.00) | KCNH2DRD2SLC6A4 | |
| Terikalant SCHEMBL1815992 | 0.72 | KCNH2 (1.00) | KCNH2DRD2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5495022-A | Piperidines and piperazines | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1996-02-27 | — | — | US | disclosed |
| EP-0634398-A1 | 4-Phenylpiperidinyl-1/-piperazinyl-1-ethylsubstituted benzofusedheterocycles as antiarrhythmic agents | MERCK PATENT GmbH (DE) | 1995-01-18 | — | — | EP | disclosed |