Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 6/20 | 0.48 |
| ▸ | DRD2 | P14416 | 5/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.43 |
| ▸ | DRD4 | P21917 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | MLNR | O43193 | 1/20 | 0.39 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.39 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.39 |
| ▸ | ESR1 | P03372 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6792592 | 0.82 | DRD2 (0.52) | KCNH2DRD2SLC6A4DRD4SIGMAR1 | |
| SCHEMBL9014370 | 0.82 | KCNH2 (0.70) | KCNH2DRD2SLC6A4DRD4SIGMAR1 | |
| SCHEMBL9014298 | 0.81 | SIGMAR1 (0.48) | KCNH2SIGMAR1 | |
| SCHEMBL9014659 | 0.79 | KCNH2 (0.57) | KCNH2DRD2SLC6A4DRD4SIGMAR1 | |
| SCHEMBL9014707 | 0.74 | DRD2 (0.52) | KCNH2DRD2DRD4SIGMAR1MEN1 | |
| SCHEMBL27539282 | 0.72 | DRD2 (0.50) | KCNH2DRD2SLC6A4SIGMAR1SLC6A2 | |
| SCHEMBL27014482 | 0.72 | DRD2 (0.50) | KCNH2DRD2SLC6A4SIGMAR1SLC6A2 | |
| SCHEMBL27015512 | 0.72 | DRD2 (0.53) | KCNH2DRD2SLC6A4SIGMAR1SLC6A2 | |
| SCHEMBL9014780 | 0.71 | KCNH2 (0.66) | KCNH2DRD2SLC6A4SIGMAR1ABCB1 | |
| SCHEMBL9014357 | 0.71 | DRD2 (0.54) | KCNH2DRD2SLC6A4DRD4SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5495022-A | Piperidines and piperazines | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1996-02-27 | — | — | US | disclosed |
| EP-0634398-A1 | 4-Phenylpiperidinyl-1/-piperazinyl-1-ethylsubstituted benzofusedheterocycles as antiarrhythmic agents | MERCK PATENT GmbH (DE) | 1995-01-18 | — | — | EP | disclosed |