SCHEMBL9014675

SCHEMBL9014675

Cc1ccc(C)c(N2CCNCC2)n1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADRB1 P08588 6/20 0.49
CYP1A2 P05177 2/20 0.44
CYP3A4 P08684 2/20 0.44
CYP2D6 P10635 2/20 0.44
TSHR P16473 2/20 0.44
CLK4 Q9HAZ1 1/20 0.44
HTR3E A5X5Y0 1/20 0.43
HTR3B O95264 1/20 0.43
HTR3A P46098 1/20 0.43
HTR3D Q70Z44 1/20 0.43
HTR3C Q8WXA8 1/20 0.43
MEN1 O00255 1/20 0.43
RECQL P46063 1/20 0.43
KMT2A Q03164 1/20 0.43
NCF1 P14598 2/20 0.43
ADRB2 P07550 1/20 0.43
PRKCI P41743 1/20 0.43
KDM4E B2RXH2 1/20 0.43
ALDH1A1 P00352 1/20 0.43
HPGD P15428 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1735647 0.82 PRKCI (0.45) ADRB1NCF1ADRB2PRKCIKDM4E
SCHEMBL31651946 0.80 HTR3E (0.49) ADRB1HTR3EHTR3BHTR3AHTR3D
SCHEMBL1735639 0.78 HRH4 (0.57) TSHRRECQLKDM4EALDH1A1HPGD
SCHEMBL27538990 0.78 HRH4 (0.47) ADRB1CYP1A2CYP3A4CYP2D6TSHR
SCHEMBL20369843 0.78 ALDH1A1 (0.54) CYP1A2CYP3A4TSHRCLK4MEN1
SCHEMBL6284789 0.76 MAPT (0.52) ADRB1CYP1A2RECQLALDH1A1
SCHEMBL2366023 0.76 HRH4 (0.46) ADRB1CYP1A2CYP3A4CYP2D6TSHR
Hydrochloric Acid SCHEMBL2366308 0.74 HRH4 (0.45) ADRB1CYP1A2CYP3A4CYP2D6TSHR
SCHEMBL2366124 0.74 ADRB1 (0.50) ADRB1CYP1A2CYP2D6TSHRHTR3E
SCHEMBL1737167 0.74 CHRNB2 (0.50) CYP1A2CYP3A4CYP2D6TSHRMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5578596-A TREATMENT OF SEROTONERGIC NEURON RELATED DISEASES, MOTION SICKNESS, ANXIXETY, DEPRESSION ASAHI KASEI KOGYO KABUSHIKI KAISHA (JP) 1996-11-26 US disclosed
EP-0668276-A1 2-ALKOXY-5,6,7,8-TETRAHYDROQUINOXALINE DERIVATIVE, PROCESS FOR PRODUCING THE SAME, AND USE THEREOF Asahi Kasei Kogyo Kabushiki Kaisha (JP) 1995-08-23 EP disclosed