Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 4/20 | 0.45 |
| ▸ | DRD3 | P35462 | 3/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.45 |
| ▸ | HTR1A | P08908 | 2/20 | 0.45 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.45 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.45 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.45 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.45 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.45 |
| ▸ | DRD4 | P21917 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9015308 | 0.88 | DRD2 (0.45) | DRD2DRD3SIGMAR1HTR1AADRA2A | |
| SCHEMBL9014693 | 0.87 | SIGMAR1 (0.55) | DRD2DRD3SIGMAR1HTR1AADRA2A | |
| SCHEMBL9014731 | 0.82 | MAPT (0.42) | DRD2DRD3SIGMAR1HTR1AADRA2A | |
| SCHEMBL7812153 | 0.76 | HTR1A (0.63) | DRD2DRD3SIGMAR1HTR1AADRA2A | |
| Hydrochloric Acid SCHEMBL10408656 | 0.75 | HTR1A (0.53) | DRD2DRD3SIGMAR1HTR1AADRA2A | |
| SCHEMBL6974927 | 0.74 | DRD2 (0.49) | DRD2DRD3SIGMAR1HTR1AADRA2A | |
| Hydrochloric Acid SCHEMBL10407883 | 0.71 | KCNH2 (0.50) | DRD2DRD3SIGMAR1HTR1AADRA2A | |
| SCHEMBL9014658 | 0.70 | MEN1 (0.41) | DRD2DRD3SIGMAR1HTR1AADRA2A | |
| SCHEMBL6801822 | 0.70 | DRD2 (0.47) | DRD2DRD3SIGMAR1HTR1AADRA2A | |
| SCHEMBL7810930 | 0.70 | HTR1A (0.60) | DRD2DRD3SIGMAR1HTR1AADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5495022-A | Piperidines and piperazines | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1996-02-27 | — | — | US | disclosed |
| EP-0634398-A1 | 4-Phenylpiperidinyl-1/-piperazinyl-1-ethylsubstituted benzofusedheterocycles as antiarrhythmic agents | MERCK PATENT GmbH (DE) | 1995-01-18 | — | — | EP | disclosed |