Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 4/20 | 0.55 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.44 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9014839 | 0.90 | DRD2 (0.54) | DRD2OPRM1KCNH2SIGMAR1CHRM4 | |
| SCHEMBL9014749 | 0.90 | DRD2 (0.53) | DRD2OPRM1SIGMAR1SLC18A3 | |
| SCHEMBL9014357 | 0.88 | DRD2 (0.54) | DRD2KCNH2SIGMAR1CHRM4DRD3 | |
| SCHEMBL9014708 | 0.88 | KCNH2 (0.61) | DRD2KCNH2ALDH1A1LMNA | |
| SCHEMBL9014679 | 0.83 | DRD2 (0.57) | DRD2OPRM1KCNH2SIGMAR1CHRM4 | |
| SCHEMBL9014782 | 0.82 | KCNH2 (0.47) | DRD2KCNH2DRD3 | |
| SCHEMBL9014725 | 0.78 | KCNH2 (0.63) | DRD2KCNH2SLC18A3 | |
| SCHEMBL11839176 | 0.74 | DRD2 (0.57) | DRD2OPRM1SIGMAR1ALDH1A1LMNA | |
| SCHEMBL6790341 | 0.73 | DRD2 (0.55) | DRD2OPRM1KCNH2SIGMAR1RAB9A | |
| SCHEMBL9014652 | 0.72 | KCNH2 (0.48) | DRD2KCNH2DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5495022-A | Piperidines and piperazines | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1996-02-27 | — | — | US | disclosed |
| EP-0634398-A1 | 4-Phenylpiperidinyl-1/-piperazinyl-1-ethylsubstituted benzofusedheterocycles as antiarrhythmic agents | MERCK PATENT GmbH (DE) | 1995-01-18 | — | — | EP | disclosed |