Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 5/20 | 0.56 |
| ▸ | HTR1A | P08908 | 8/20 | 0.48 |
| ▸ | HTR2A | P28223 | 7/20 | 0.48 |
| ▸ | DRD3 | P35462 | 6/20 | 0.48 |
| ▸ | HTR2C | P28335 | 2/20 | 0.47 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.46 |
| ▸ | HTR3B | O95264 | 1/20 | 0.46 |
| ▸ | HTR3A | P46098 | 1/20 | 0.46 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.46 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.41 |
| ▸ | HTR7 | P34969 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 2/20 | 0.40 |
| ▸ | DRD4 | P21917 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9014817 | 0.88 | HTR1A (0.52) | KCNH2HTR1AHTR2ADRD3HTR2C | |
| SCHEMBL9014895 | 0.88 | HTR1A (0.42) | KCNH2HTR1AHTR2ADRD3HTR2C | |
| SCHEMBL9014945 | 0.88 | HTR1A (0.42) | KCNH2HTR1AHTR2ADRD3HTR2C | |
| SCHEMBL9014870 | 0.87 | HTR3E (0.45) | KCNH2HTR1AHTR2ADRD3HTR2C | |
| SCHEMBL9014775 | 0.86 | DRD2 (0.41) | KCNH2HTR1AHTR2ADRD3HTR2C | |
| SCHEMBL9014678 | 0.85 | KCNH2 (0.40) | KCNH2HTR1AHTR2ADRD3HTR2C | |
| SCHEMBL9014815 | 0.85 | KCNH2 (0.55) | KCNH2HTR1AHTR2ADRD3HRH3 | |
| SCHEMBL9014874 | 0.85 | DRD2 (0.49) | KCNH2HTR1AHTR2ADRD3HTR2C | |
| SCHEMBL9014858 | 0.84 | KCNH2 (0.57) | KCNH2HTR1AHTR2ADRD3HRH3 | |
| SCHEMBL9265535 | 0.84 | KDM4E (0.44) | KCNH2HTR1AHTR2ADRD3HTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5578596-A | TREATMENT OF SEROTONERGIC NEURON RELATED DISEASES, MOTION SICKNESS, ANXIXETY, DEPRESSION | ASAHI KASEI KOGYO KABUSHIKI KAISHA (JP) | 1996-11-26 | — | — | US | disclosed |
| EP-0668276-A1 | 2-ALKOXY-5,6,7,8-TETRAHYDROQUINOXALINE DERIVATIVE, PROCESS FOR PRODUCING THE SAME, AND USE THEREOF | Asahi Kasei Kogyo Kabushiki Kaisha (JP) | 1995-08-23 | — | — | EP | disclosed |