SCHEMBL901534

SCHEMBL901534

Nc1nc(CCc2ccccc2)c(-c2ccccc2)n1Cc1ccccc1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 6/20 0.44
PDE6D O43924 1/20 0.44
ALDH2 P05091 1/20 0.44
ALDH3A1 P30838 1/20 0.44
CFTR P13569 1/20 0.43
TNF P01375 2/20 0.42
CXCL8 P10145 1/20 0.42
SOS1 Q07889 1/20 0.42
NOD2 Q9HC29 1/20 0.42
NOD1 Q9Y239 1/20 0.42
LMNA P02545 2/20 0.41
RECQL P46063 1/20 0.41
RAB9A P51151 1/20 0.41
SMN1; SMN2 Q16637 1/20 0.41
KDM4E B2RXH2 1/20 0.41
HPGD P15428 1/20 0.41
PNP P00491 3/20 0.41
CYP1A2 P05177 2/20 0.40
CYP3A4 P08684 2/20 0.40
CYP2C9 P11712 2/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL939417 0.69 TNF (0.79) ALDH1A1PDE6DALDH2ALDH3A1CFTR
SCHEMBL5175302 0.67 KDM4E (0.50) ALDH1A1TNFCXCL8SOS1NOD2
SCHEMBL8233014 0.67 MEN1 (0.57) ALDH1A1LMNASMN1; SMN2KDM4EHPGD
SCHEMBL27888661 0.65 ALDH1A1 (0.49) ALDH1A1PDE6DALDH2ALDH3A1CFTR
SCHEMBL11715808 0.65 CXCR4 (0.72) TNFCXCL8SOS1NOD2NOD1
SCHEMBL18152788 0.65 ALDH1A1 (0.61) ALDH1A1PDE6DALDH2ALDH3A1CFTR
SCHEMBL6565290 0.64 KDM4E (0.43) ALDH1A1TNFCXCL8SOS1NOD2
SCHEMBL7165480 0.64 TNF (0.87) ALDH1A1PDE6DALDH2ALDH3A1TNF
SCHEMBL28111190 0.64 CFTR (0.50) ALDH1A1PDE6DALDH2ALDH3A1CFTR
Bromide SCHEMBL11712562 0.64 CXCR4 (0.70) TNFCXCL8SOS1NOD2NOD1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2012041934-A1 POLYSUBSTITUTED 2-AMINOIMIDAZOLES FOR CONTROLLING BIOFILMS AND PROCESS FOR THEIR PRODUCTION KATHOLIEKE UNIVERSITEIT LEUVEN (BE) 2012-04-05 WO claimed
WO-2012041934-A1 POLYSUBSTITUTED 2-AMINOIMIDAZOLES FOR CONTROLLING BIOFILMS AND PROCESS FOR THEIR PRODUCTION KATHOLIEKE UNIVERSITEIT LEUVEN (BE) 2012-04-05 WO disclosed
WO-2012041934-A1 POLYSUBSTITUTED 2-AMINOIMIDAZOLES FOR CONTROLLING BIOFILMS AND PROCESS FOR THEIR PRODUCTION KATHOLIEKE UNIVERSITEIT LEUVEN (BE) 2012-04-05 WO disclosed