Known targets — ChEMBL curated mechanism
ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3CHRM1CHRM2CHRM3CHRM4ESR1ESR2GABRA1GABRB1GABRG2GBA1HRH1HTR1DHTR2AOPRD1OPRK1OPRM1SLC6A2SLC6A3TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8rplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Cadaverine Tartrate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 3/20 | 0.48 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.46 |
| ▸ | CTSK | P43235 | 3/20 | 0.43 |
| ▸ | LTA4H | P09960 | 2/20 | 0.43 |
| ▸ | CTRB1 | P17538 | 2/20 | 0.42 |
| ▸ | ACE | P12821 | 2/20 | 0.41 |
| ▸ | ACE2 | Q9BYF1 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | ANPEP | P15144 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | LAP3 | P28838 | 1/20 | 0.39 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.38 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cadaverine Tartrate SCHEMBL8712134 | 0.82 | ATM (0.57) | CTSKACECYP3A4 | |
| Cadaverine Tartrate SCHEMBL7207472 | 0.82 | ATM (0.57) | CTSKACECYP3A4 | |
| SCHEMBL8749524 | 0.78 | CYP3A4 (0.55) | CTSKCTRB1ACEACE2NPC1 | |
| SCHEMBL29603779 | 0.78 | CYP3A4 (0.55) | CTSKCTRB1ACEACE2NPC1 | |
| SCHEMBL9938716 | 0.78 | MME (0.62) | ACE | |
| SCHEMBL29604304 | 0.77 | CTSK (0.52) | CTSKCTRB1ACEACE2NPC1 | |
| SCHEMBL2059435 | 0.77 | ATM (0.61) | CTSKACECYP3A4 | |
| SCHEMBL31506428 | 0.77 | ATM (0.61) | CTSKACECYP3A4 | |
| SCHEMBL8910000 | 0.77 | ATM (0.61) | CTSKACECYP3A4 | |
| SCHEMBL22305235 | 0.77 | ATM (0.61) | CTSKACECYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5565604-A | Process for the preparation of a substituted 2,5-diamino-3-hydroxyhexane | ABBOTT LABORATORIES (US) | 1996-10-15 | — | — | US | disclosed |