Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | ACHE | P22303 | 2/20 | 0.36 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 5/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.35 |
| ▸ | KIF11 | P52732 | 3/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.35 |
| ▸ | MAPT | P10636 | 4/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | ELANE | P08246 | 1/20 | 0.33 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1326257 | 0.84 | KCNN4 (0.36) | TSHRKIF11ALDH1A1CYP2C9CYP1A2 | |
| SCHEMBL9016337 | 0.80 | CNR1 (0.40) | TSHRLMNAACHEMEN1KMT2A | |
| SCHEMBL7714999 | 0.79 | TSHR (0.48) | TSHRLMNAACHEALOX12MEN1 | |
| SCHEMBL7179934 | 0.78 | TSHR (0.55) | TSHRLMNAACHEALOX12KIF11 | |
| SCHEMBL19002958 | 0.77 | KCNN4 (0.31) | TSHRALDH1A1 | |
| Iodide SCHEMBL11522125 | 0.76 | TSHR (0.52) | TSHRLMNAACHEALOX12KIF11 | |
| SCHEMBL9016328 | 0.76 | ACHE (0.39) | TSHRACHETDP1ALDH1A1NPC1 | |
| SCHEMBL411476 | 0.74 | ALDH1A1 (0.38) | TSHRKIF11TDP1NPSR1ALDH1A1 | |
| SCHEMBL19002936 | 0.74 | NPC1 (0.32) | L3MBTL1ALDH1A1NPC1RAB9A | |
| Bromide SCHEMBL659623 | 0.72 | ALDH1A1 (0.37) | TSHRKIF11TDP1ALDH1A1HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0683786-B1 | PROCESS FOR THE PREPARATION OF LITHIUM DIARYLPHOSPHIDES AND ALKYLATED DERIVATIVES THEREOF | EASTMAN CHEM CO (US) | 1996-12-18 | — | — | EP | disclosed |
| EP-0683786-A1 | PROCESS FOR THE PREPARATION OF LITHIUM DIARYLPHOSPHIDES AND ALKYLATED DERIVATIVES THEREOF. | EASTMAN CHEM CO (US) | 1995-11-29 | — | — | EP | disclosed |
| US-5354894-A | Treating triarylphosphine with lithium and a primary or secondary amine | EASTMAN CHEMICAL COMPANY (US) | 1994-10-11 | — | — | US | disclosed |
| WO-1994018211-A1 | PROCESS FOR THE PREPARATION OF LITHIUM DIARYLPHOSPHIDES AND ALKYLATED DERIVATIVES THEREOF | EASTMAN CHEMICAL COMPANY (US) | 1994-08-18 | — | — | WO | disclosed |
| US-5288912-A | Hydrohalogenation of a triarylphosphine; alkylation; using lithium diarylphosphine as chemical intermediate | EASTMAN KODAK COMPANY (US) | 1994-02-22 | — | — | US | disclosed |