Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.39 |
| ▸ | ACHE | P22303 | 3/20 | 0.39 |
| ▸ | KIF11 | P52732 | 1/20 | 0.36 |
| ▸ | KCNN4 | O15554 | 4/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.34 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.34 |
| ▸ | ESR1 | P03372 | 1/20 | 0.34 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | CA7 | P43166 | 1/20 | 0.32 |
| ▸ | CA9 | Q16790 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.32 |
| ▸ | SCN4A | P35499 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15660504 | 0.95 | TSHR (0.39) | TSHRACHEKIF11KCNN4MAPK1 | |
| Bromide SCHEMBL29017423 | 0.93 | TSHR (0.38) | TSHRACHEKIF11KCNN4MAPK1 | |
| Water SCHEMBL29265399 | 0.93 | TSHR (0.38) | TSHRACHEKIF11KCNN4MAPK1 | |
| Iodide SCHEMBL11522127 | 0.83 | TSHR (0.45) | TSHRACHEGABRA1GABRB2ESR1 | |
| SCHEMBL5596345 | 0.82 | GABRA1 (0.55) | TSHRACHEKIF11GABRA1GABRB2 | |
| SCHEMBL15657789 | 0.79 | TRPA1 (0.35) | TSHRACHEKIF11KCNN4GABRA1 | |
| SCHEMBL1368134 | 0.78 | KCNN4 (0.41) | TSHRKCNN4MAPK1ESR1ESR2 | |
| SCHEMBL9016328 | 0.77 | ACHE (0.39) | TSHRACHEGABRA1GABRB2ALDH1A1 | |
| SCHEMBL10887966 | 0.77 | TSHR (0.35) | TSHRACHEKIF11KCNN4MAPK1 | |
| SCHEMBL9632116 | 0.76 | TSHR (0.43) | TSHRACHEKIF11KCNN4MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0683786-B1 | PROCESS FOR THE PREPARATION OF LITHIUM DIARYLPHOSPHIDES AND ALKYLATED DERIVATIVES THEREOF | EASTMAN CHEM CO (US) | 1996-12-18 | — | — | EP | disclosed |
| EP-0683786-A1 | PROCESS FOR THE PREPARATION OF LITHIUM DIARYLPHOSPHIDES AND ALKYLATED DERIVATIVES THEREOF. | EASTMAN CHEM CO (US) | 1995-11-29 | — | — | EP | disclosed |
| US-5354894-A | Treating triarylphosphine with lithium and a primary or secondary amine | EASTMAN CHEMICAL COMPANY (US) | 1994-10-11 | — | — | US | disclosed |
| WO-1994018211-A1 | PROCESS FOR THE PREPARATION OF LITHIUM DIARYLPHOSPHIDES AND ALKYLATED DERIVATIVES THEREOF | EASTMAN CHEMICAL COMPANY (US) | 1994-08-18 | — | — | WO | disclosed |
| US-5288912-A | Hydrohalogenation of a triarylphosphine; alkylation; using lithium diarylphosphine as chemical intermediate | EASTMAN KODAK COMPANY (US) | 1994-02-22 | — | — | US | disclosed |