Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.56 |
| ▸ | MAPT | P10636 | 3/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.56 |
| ▸ | MITF | O75030 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.56 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | CASP1 | P29466 | 1/20 | 0.50 |
| ▸ | CASP7 | P55210 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 4/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | POLB | P06746 | 3/20 | 0.47 |
| ▸ | AR | P10275 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Potassium Ion SCHEMBL7181717 | 1.00 | MEN1 (0.56) | MEN1KMT2AMAPTTDP1MITF | |
| SCHEMBL10800186 | 0.96 | MEN1 (0.56) | MEN1KMT2AMAPTTDP1MITF | |
| SCHEMBL3870643 | 0.96 | KDM4E (0.57) | MEN1KMT2AMAPTTDP1MITF | |
| SCHEMBL9498626 | 0.96 | MEN1 (0.56) | MEN1KMT2AMAPTTDP1MITF | |
| SCHEMBL9017418 | 0.96 | KDM4E (0.57) | MEN1KMT2AMAPTTDP1MITF | |
| Zinc Ion SCHEMBL5964694 | 0.96 | MEN1 (0.56) | MEN1KMT2AMAPTTDP1MITF | |
| SCHEMBL6697934 | 0.96 | MEN1 (0.56) | MEN1KMT2AMAPTTDP1MITF | |
| SCHEMBL8411322 | 0.96 | MEN1 (0.56) | MEN1KMT2AMAPTTDP1MITF | |
| Lithium Ion SCHEMBL5874911 | 0.96 | MEN1 (0.56) | MEN1KMT2AMAPTTDP1MITF | |
| SCHEMBL9808578 | 0.96 | MEN1 (0.56) | MEN1KMT2AMAPTTDP1MITF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5543564-A | Process for releasing acidic organic compounds from salts thereof by carbon dioxide | HOECHST AKTIENGESELLSCHAFT (DE) | 1996-08-06 | — | — | US | disclosed |
| EP-0066205-B1 | PROCESS FOR PREPARATION OF 2-HYDROXYNAPHTHALENE-3-CARBOXYLIC ACID | Kabushiki Kaisha Ueno Seiyaku Oyo Kenkyujo (JP) | 1985-09-04 | — | — | EP | disclosed |
| EP-0066205-A1 | Process for preparation of 2-hydroxynaphthalene-3-carboxylic acid | Kabushiki Kaisha Ueno Seiyaku Oyo Kenkyujo (JP) | 1982-12-08 | — | — | EP | disclosed |