Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | NCEH1 | Q6PIU2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9017874 | 1.00 | GAA (0.37) | GAAALDH1A1KDM4EHSD17B10MAPT | |
| SCHEMBL9017864 | 0.91 | BCHE (0.38) | ALDH1A1KDM4EHSD17B10RAB9ATSHR | |
| SCHEMBL9017860 | 0.91 | BCHE (0.38) | ALDH1A1KDM4EHSD17B10RAB9ATSHR | |
| SCHEMBL9017892 | 0.90 | ACHE (0.39) | RAB9ATSHRNCEH1 | |
| SCHEMBL9017875 | 0.90 | ACHE (0.39) | RAB9ATSHRNCEH1 | |
| SCHEMBL9017879 | 0.90 | ACHE (0.39) | RAB9ATSHRNCEH1 | |
| SCHEMBL9017889 | 0.90 | ACHE (0.39) | RAB9ATSHRNCEH1 | |
| SCHEMBL9017869 | 0.87 | NCEH1 (0.33) | ALDH1A1KDM4EHSD17B10RAB9ATSHR | |
| SCHEMBL9017868 | 0.87 | NCEH1 (0.33) | ALDH1A1KDM4EHSD17B10RAB9ATSHR | |
| Dimethylcarbate SCHEMBL9680337 | 0.81 | GAA (0.40) | GAAALDH1A1HSD17B10MAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0477903-B1 | Substituted-4-amino-3-pyridinols, a process for their preparation and their use as medicaments | HOECHST ROUSSEL PHARMA (US) | 1996-04-03 | — | — | EP | disclosed |
| EP-0477903-A2 | Substituted-4-amino-3-pyridinols, a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1992-04-01 | — | — | EP | disclosed |