Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NCEH1 | Q6PIU2 | 6/20 | 0.37 |
| ▸ | BCHE | P06276 | 4/20 | 0.35 |
| ▸ | ACHE | P22303 | 2/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | KDM6B | O15054 | 1/20 | 0.33 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Maleic Acid SCHEMBL9017901 | 0.95 | KDM4E (0.34) | NCEH1BCHEACHENPSR1MAPT | |
| SCHEMBL9017921 | 0.87 | MAPT (0.37) | NCEH1BCHEACHEMAPTLMNA | |
| SCHEMBL9017917 | 0.87 | MAPT (0.37) | NCEH1BCHEACHEMAPTLMNA | |
| SCHEMBL9017940 | 0.86 | NCEH1 (0.34) | NCEH1BCHEACHEPDE4BLMNA | |
| SCHEMBL9017939 | 0.86 | NCEH1 (0.34) | NCEH1BCHEACHEPDE4BLMNA | |
| SCHEMBL9017888 | 0.83 | BCHE (0.35) | NCEH1BCHEACHEPDE4BLMNA | |
| SCHEMBL9017846 | 0.83 | RAB9A (0.38) | NCEH1BCHETSHRLMNA | |
| SCHEMBL9017843 | 0.83 | RAB9A (0.38) | NCEH1BCHETSHRLMNA | |
| Fumaric Acid SCHEMBL9017933 | 0.82 | MAPT (0.34) | NCEH1NPSR1MAPTLMNAHTT | |
| Maleic Acid SCHEMBL9017929 | 0.82 | MAPT (0.34) | NCEH1NPSR1MAPTLMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0477903-B1 | Substituted-4-amino-3-pyridinols, a process for their preparation and their use as medicaments | HOECHST ROUSSEL PHARMA (US) | 1996-04-03 | — | — | EP | disclosed |
| EP-0477903-A2 | Substituted-4-amino-3-pyridinols, a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1992-04-01 | — | — | EP | disclosed |