Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.60 |
| ▸ | HPGD | P15428 | 1/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 4/20 | 0.50 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.50 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | SGMS1 | Q86VZ5 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | NAMPT | P43490 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9018559 | 0.88 | MEN1 (0.53) | ALDH1A1HPGDKMT2ASMN1; SMN2MEN1 | |
| SCHEMBL9574735 | 0.88 | ALDH1A1 (0.52) | ALDH1A1HPGDKMT2ASMN1; SMN2POLB | |
| SCHEMBL9018365 | 0.87 | L3MBTL1 (0.61) | ALDH1A1HPGDKMT2AMEN1GAA | |
| SCHEMBL9018028 | 0.86 | PTPN1 (0.53) | ALDH1A1HPGDSMN1; SMN2POLBSGMS1 | |
| SCHEMBL9018162 | 0.86 | SMN1; SMN2 (0.54) | ALDH1A1HPGDKMT2ASMN1; SMN2HSD17B10 | |
| SCHEMBL9018308 | 0.86 | P4HTM (0.46) | ALDH1A1HPGDKMT2ASMN1; SMN2POLB | |
| SCHEMBL7871607 | 0.86 | ALDH1A1 (0.52) | ALDH1A1HPGDKMT2ASMN1; SMN2POLB | |
| SCHEMBL7862776 | 0.85 | L3MBTL1 (0.54) | ALDH1A1HPGDKMT2ASMN1; SMN2MEN1 | |
| SCHEMBL9140161 | 0.85 | ALDH1A1 (0.59) | ALDH1A1HPGDKMT2ASMN1; SMN2POLB | |
| SCHEMBL9018504 | 0.85 | CA12 (0.46) | ALDH1A1HPGDKMT2APOLBHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0590520-B1 | Acylsulphonamido and sulphonamidopyridine-2-carboxylic acid esters, pyridine-n-oxides thereof, a process for their preparation and their use as medicaments | HOECHST AG (DE) | 1996-06-12 | — | — | EP | disclosed |
| EP-0590520-A1 | Acylsulphonamido and sulphonamidopyridine-2-carboxylic acid esters, pyridine-n-oxides thereof, a process for their preparation and their use as medicaments | HOECHST AKTIENGESELLSCHAFT (DE) | 1994-04-06 | — | — | EP | disclosed |