Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P4HTM | Q9NXG6 | 4/20 | 0.53 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.45 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.44 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 3/20 | 0.42 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.41 |
| ▸ | BCL2L1 | Q07817 | 2/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.40 |
| ▸ | ALKBH2 | Q6NS38 | 1/20 | 0.40 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.40 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9018024 | 0.93 | P4HTM (0.56) | P4HTMPTGS2PTGS1GABRA5EGFR | |
| SCHEMBL9018013 | 0.88 | P4HTM (0.58) | P4HTMPTGS2PTGS1GABRA5EGFR | |
| SCHEMBL9018292 | 0.84 | HSD17B10 (0.48) | — | |
| SCHEMBL7870518 | 0.84 | P4HTM (0.64) | P4HTMPTGS2PTGS1EGFRBCL2L1 | |
| SCHEMBL9018238 | 0.82 | KMT2A (0.43) | P4HTMKAT6ABCL2L1MCL1 | |
| SCHEMBL9018433 | 0.82 | CTDSP1 (0.41) | — | |
| SCHEMBL9018213 | 0.81 | SMN1; SMN2 (0.45) | P4HTMKAT6ABCL2L1MCL1 | |
| SCHEMBL9018214 | 0.81 | P4HTM (0.55) | P4HTMPTGS2PTGS1GABRA5EGFR | |
| SCHEMBL7874636 | 0.81 | P4HTM (0.52) | P4HTMEGFRBCL2L1MCL1 | |
| SCHEMBL9018209 | 0.81 | L3MBTL1 (0.50) | P4HTMBCL2L1MCL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0590520-B1 | Acylsulphonamido and sulphonamidopyridine-2-carboxylic acid esters, pyridine-n-oxides thereof, a process for their preparation and their use as medicaments | HOECHST AG (DE) | 1996-06-12 | — | — | EP | disclosed |
| EP-0590520-A1 | Acylsulphonamido and sulphonamidopyridine-2-carboxylic acid esters, pyridine-n-oxides thereof, a process for their preparation and their use as medicaments | HOECHST AKTIENGESELLSCHAFT (DE) | 1994-04-06 | — | — | EP | disclosed |