Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P4HTM | Q9NXG6 | 4/20 | 0.56 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.47 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.46 |
| ▸ | EGFR | P00533 | 4/20 | 0.45 |
| ▸ | KAT6A | Q92794 | 2/20 | 0.42 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.41 |
| ▸ | BCL2L1 | Q07817 | 2/20 | 0.41 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.40 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.40 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9018025 | 0.93 | P4HTM (0.53) | P4HTMPTGS2PTGS1EGFRKAT6A | |
| SCHEMBL9018013 | 0.91 | P4HTM (0.58) | P4HTMPTGS2PTGS1EGFRGABRA5 | |
| SCHEMBL9018391 | 0.86 | L3MBTL1 (0.56) | BCL2L1MCL1HDAC1HDAC2 | |
| SCHEMBL9018089 | 0.86 | HTT (0.51) | P4HTMHDAC2HDAC8HDAC6 | |
| SCHEMBL9018099 | 0.86 | SMN1; SMN2 (0.43) | P4HTMKAT6AGABRA5BCL2L1MCL1 | |
| SCHEMBL7870518 | 0.86 | P4HTM (0.64) | P4HTMPTGS2PTGS1EGFRBCL2L1 | |
| SCHEMBL9018134 | 0.86 | RAB9A (0.49) | P4HTMHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL9018341 | 0.85 | RAB9A (0.50) | KAT6ABCL2L1MCL1HDAC3HDAC4 | |
| SCHEMBL9018209 | 0.85 | L3MBTL1 (0.50) | P4HTMBCL2L1MCL1HDAC3HDAC4 | |
| SCHEMBL9018147 | 0.84 | RAB9A (0.44) | P4HTMHDAC2HDAC8HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0590520-B1 | Acylsulphonamido and sulphonamidopyridine-2-carboxylic acid esters, pyridine-n-oxides thereof, a process for their preparation and their use as medicaments | HOECHST AG (DE) | 1996-06-12 | — | — | EP | disclosed |
| EP-0590520-A1 | Acylsulphonamido and sulphonamidopyridine-2-carboxylic acid esters, pyridine-n-oxides thereof, a process for their preparation and their use as medicaments | HOECHST AKTIENGESELLSCHAFT (DE) | 1994-04-06 | — | — | EP | disclosed |