Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P4HTM | Q9NXG6 | 4/20 | 0.58 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.49 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.48 |
| ▸ | EGFR | P00533 | 4/20 | 0.46 |
| ▸ | P2RY12 | Q9H244 | 2/20 | 0.43 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.42 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.42 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | PTGES | O14684 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9018024 | 0.91 | P4HTM (0.56) | P4HTMPTGS2PTGS1EGFRBCL2L1 | |
| SCHEMBL9018016 | 0.89 | SCN3A (0.49) | P4HTM | |
| SCHEMBL9018025 | 0.88 | P4HTM (0.53) | P4HTMPTGS2PTGS1EGFRBCL2L1 | |
| SCHEMBL9018429 | 0.88 | NPC1 (0.51) | P4HTMMAPT | |
| SCHEMBL7870518 | 0.88 | P4HTM (0.64) | P4HTMPTGS2PTGS1EGFRBCL2L1 | |
| SCHEMBL9018017 | 0.88 | EGFR (0.45) | P4HTMPTGS2EGFRGABRA5 | |
| SCHEMBL9018335 | 0.88 | P4HTM (0.60) | P4HTMEGFRMAPT | |
| SCHEMBL9018008 | 0.87 | KAT6A (0.47) | P4HTMBCL2L1MCL1 | |
| SCHEMBL9018251 | 0.87 | MAPT (0.49) | P4HTMBCL2L1MCL1MAPT | |
| SCHEMBL9018048 | 0.87 | NPC1 (0.52) | P4HTMBCL2L1MCL1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0590520-B1 | Acylsulphonamido and sulphonamidopyridine-2-carboxylic acid esters, pyridine-n-oxides thereof, a process for their preparation and their use as medicaments | HOECHST AG (DE) | 1996-06-12 | — | — | EP | disclosed |
| EP-0590520-A1 | Acylsulphonamido and sulphonamidopyridine-2-carboxylic acid esters, pyridine-n-oxides thereof, a process for their preparation and their use as medicaments | HOECHST AKTIENGESELLSCHAFT (DE) | 1994-04-06 | — | — | EP | disclosed |