Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.38 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.38 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.37 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.37 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.37 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.37 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.37 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.37 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.37 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5163 | 0.80 | GABRP (0.52) | SMN1; SMN2MEN1KMT2AALDH1A1CHRNB2 | |
| SCHEMBL27030505 | 0.80 | GABRP (0.52) | SMN1; SMN2MEN1KMT2AALDH1A1CHRNB2 | |
| Bromide SCHEMBL11553713 | 0.78 | CHRNB2 (0.50) | SMN1; SMN2MEN1KMT2AALDH1A1CHRNB2 | |
| Hydrochloric Acid SCHEMBL27569873 | 0.78 | CHRNB2 (0.50) | SMN1; SMN2MEN1KMT2AALDH1A1CHRNB2 | |
| Potassium SCHEMBL31108386 | 0.78 | CHRNB2 (0.50) | SMN1; SMN2MEN1KMT2AALDH1A1CHRNB2 | |
| Hydrochloric Acid SCHEMBL774514 | 0.78 | CHRNB2 (0.50) | SMN1; SMN2MEN1KMT2AALDH1A1CHRNB2 | |
| SCHEMBL25153864 | 0.77 | LMNA (0.51) | LMNASMN1; SMN2MEN1KMT2AL3MBTL1 | |
| SCHEMBL29248610 | 0.77 | LMNA (0.51) | LMNASMN1; SMN2MEN1KMT2AL3MBTL1 | |
| SCHEMBL901378 | 0.75 | LMNA (0.66) | LMNASMN1; SMN2MEN1KMT2AL3MBTL1 | |
| SCHEMBL901803 | 0.75 | PDGFRB (0.50) | LMNASMN1; SMN2MEN1KMT2AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | disclosed |
| WO-2012041476-A1 | PYRIDINE AND ISOQUINOLINE DERIVATIVES AS SYK- AND JAK-KINASE INHIBITORS | ALMIRALL, S.A. (ES) | 2012-04-05 | — | — | WO | disclosed |