Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 3/20 | 0.57 |
| ▸ | HTR2A | P28223 | 3/20 | 0.57 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.57 |
| ▸ | HTR1A | P08908 | 2/20 | 0.57 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.57 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.57 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.57 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.57 |
| ▸ | DRD2 | P14416 | 1/20 | 0.57 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.57 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.57 |
| ▸ | DRD1 | P21728 | 1/20 | 0.57 |
| ▸ | ACHE | P22303 | 1/20 | 0.57 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.57 |
| ▸ | HTR2C | P28335 | 1/20 | 0.57 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.57 |
| ▸ | CCKBR | P32239 | 1/20 | 0.57 |
| ▸ | HRH1 | P35367 | 1/20 | 0.57 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.57 |
| ▸ | DRD3 | P35462 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9596902 | 0.90 | ADRA1A (0.51) | DRD4HTR2AADRA1AHTR1AABCB11 | |
| SCHEMBL9597973 | 0.90 | HTR1A (0.47) | DRD4HTR2AADRA1AHTR1AABCB11 | |
| SCHEMBL9018128 | 0.89 | ADRA1A (0.52) | DRD4HTR2AADRA1AHTR1AABCB11 | |
| SCHEMBL9597499 | 0.89 | HTR1A (0.52) | DRD4HTR2AADRA1AHTR1AABCB11 | |
| SCHEMBL9018113 | 0.86 | HTR2A (0.54) | DRD4HTR2AADRA1AHTR1ADRD2 | |
| SCHEMBL9018038 | 0.86 | DRD2 (0.54) | DRD4HTR2AADRA1AHTR1ADRD2 | |
| SCHEMBL9018354 | 0.85 | HTR1A (0.48) | DRD4HTR2AADRA1AHTR1ADRD2 | |
| SCHEMBL8558649 | 0.84 | HRH3 (0.47) | DRD4HTR2AADRA1AHTR1AABCB11 | |
| SCHEMBL9018175 | 0.81 | HTR2A (0.49) | DRD4HTR2AADRA1AHTR1ADRD2 | |
| SCHEMBL8552021 | 0.81 | MEN1 (0.48) | DRD4HTR2AADRA1AHTR1AABCB11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0570850-B1 | Benzo(b)thiophen-3-yl-piperazines, a process for their preparation and their use as medicaments | HOECHST MARION ROUSSEL INC (US) | 1996-12-11 | — | — | EP | claimed |
| EP-0570850-A1 | Benzo(b)thiophen-3-yl-piperazines, a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1993-11-24 | — | — | EP | claimed |
| JP-6009617-A | — | — | None | — | — | JP | disclosed |
| EP-0570850-B1 | Benzo(b)thiophen-3-yl-piperazines, a process for their preparation and their use as medicaments | HOECHST MARION ROUSSEL INC (US) | 1996-12-11 | — | — | EP | disclosed |
| JP-H069617-A | BENZO(B)THIOPHEN-3-YL-PIPERAZINE, ITS PRODUCTION AND ITS USE AS MEDICINE | HOECHST ROUSSEL PHARMACEUT INC | 1994-01-18 | — | — | JP | disclosed |
| EP-0570850-A1 | Benzo(b)thiophen-3-yl-piperazines, a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1993-11-24 | — | — | EP | disclosed |
| US-5240927-A | Benzo[β]thiophen-3-yl piperazines as antipsychotic agents | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1993-08-31 | — | — | US | disclosed |