Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 4/20 | 0.54 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.51 |
| ▸ | HTR2A | P28223 | 5/20 | 0.47 |
| ▸ | DRD4 | P21917 | 3/20 | 0.47 |
| ▸ | HTR1A | P08908 | 3/20 | 0.46 |
| ▸ | DRD3 | P35462 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9018047 | 0.86 | DRD4 (0.57) | DRD2ADRA1AHTR2ADRD4HTR1A | |
| SCHEMBL9018113 | 0.84 | HTR2A (0.54) | DRD2ADRA1AHTR2ADRD4HTR1A | |
| SCHEMBL9018128 | 0.82 | ADRA1A (0.52) | DRD2ADRA1AHTR2ADRD4HTR1A | |
| SCHEMBL9018034 | 0.81 | HTR2A (0.56) | DRD2ADRA1AHTR2ADRD4HTR1A | |
| SCHEMBL9596902 | 0.81 | ADRA1A (0.51) | DRD2ADRA1AHTR2ADRD4HTR1A | |
| SCHEMBL9018354 | 0.80 | HTR1A (0.48) | DRD2ADRA1AHTR2ADRD4HTR1A | |
| SCHEMBL11170700 | 0.79 | MAPT (0.57) | DRD2HTR2AHTR1AKDM4EALDH1A1 | |
| SCHEMBL1544952 | 0.78 | HTR1A (0.56) | DRD2ADRA1AHTR2ADRD4HTR1A | |
| SCHEMBL9018175 | 0.78 | HTR2A (0.49) | DRD2ADRA1AHTR2ADRD4HTR1A | |
| Mafoprazine SCHEMBL2111008 | 0.77 | DRD2 (0.66) | DRD2HTR2ADRD4HTR1ADRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0570850-B1 | Benzo(b)thiophen-3-yl-piperazines, a process for their preparation and their use as medicaments | HOECHST MARION ROUSSEL INC (US) | 1996-12-11 | — | — | EP | disclosed |
| EP-0570850-A1 | Benzo(b)thiophen-3-yl-piperazines, a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1993-11-24 | — | — | EP | disclosed |
| US-5240927-A | Benzo[β]thiophen-3-yl piperazines as antipsychotic agents | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1993-08-31 | — | — | US | disclosed |